RNA-based therapeutics to treat human fungal infections.
RNA-based therapeutics
antifungal
fungal infection
fungi
medical mycology
Journal
Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
10
06
2021
revised:
03
09
2021
accepted:
14
09
2021
pubmed:
13
10
2021
medline:
15
4
2022
entrez:
12
10
2021
Statut:
ppublish
Résumé
In recent decades, RNA-based therapeutics have transitioned from a near impossibility to a compelling treatment alternative for genetic disorders and infectious diseases. The mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are truly groundbreaking, and new adaptations are already being proposed to fight other microbes. Unfortunately, the potential of RNA-based therapeutics to treat human fungal infections has remained mostly absent from the conversation, despite the fact that invasive fungal infections kill as many per year as tuberculosis and even more than malaria. Here, we argue that RNA-based therapeutics should be investigated for the treatment of human fungal infections and discuss several major roadblocks and potential circumventions that may allow for the realization of RNA-based therapies against human fungal pathogens.
Identifiants
pubmed: 34635448
pii: S0966-842X(21)00218-3
doi: 10.1016/j.tim.2021.09.007
pmc: PMC8498853
pii:
doi:
Substances chimiques
RNA
63231-63-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
411-420Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests There are no interests to declare.
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