Prospective randomised trial examining the impact of an educational intervention versus usual care on anticoagulation therapy control based on an SAMe-TT

The burden of atrial fibrillation (AF) in Thailand is high and associated with increased morbidity, mortality and healthcare costs. Vitamin K antagonists (eg, warfarin), commonly used for stroke prevention in patients with AF in Thailand, are effective but are often suboptimally controlled. We aim to evaluate the impact of an SAMe-TT Multicentre, open-label, parallel-group, randomised controlled trial conducted in Thailand among adult patients (age: 18 years) with AF who are anticoagulant naïve. Patients will be randomised to one of two groups; an SAMe-TT The study has been approved by the Ethical Review Committee, Ministry of Public Health of Thailand, and registered in the Thai Clinical Trials Registry. The results of this trial will be submitted for publication in a peer-reviewed journal. Participants will be informed via a link to a preview of the publication. A lay summary will also be provided to all participants prior to publication. TCTR20180711003.

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: All other authors have no actual or potential conflict of interest capable of influencing judgment on the part of any author on this work. AP and WW: reports speaker fees from Bayer, Pfizer, Boehringer Ingelheim, and Daiichi-Sankyo outside the submitted work. DL: reports investigator-initiated educational grants from Bristol-Myers Squibb (BMS); speaker fees for Boehringer Ingelheim, Bayer and BMS/Pfizer; and consultancy for BMS/Pfizer, Boehringer Ingelheim and Daiichi-Sankyo, all outside of the submitted work. GL: reports consultancy and speaker fees for BMS/Pfizer, Boehringer Ingelheim and Daiichi-Sankyo. No fees are received personally.