Anti-microtubule activity of the traditional Chinese medicine herb Northern Ban Lan (Isatis tinctoria) leads to glucobrassicin.
Isatis tinctoria
Northern Ban Lan
anti-microtubule activity
cytoskeleton
glucobrassicin
high-performance liquid chromatography (HPLC)
high-resolution tandem mass spectrometry (HRMS/MS)
traditional Chinese medicine (TCM)
Journal
Journal of integrative plant biology
ISSN: 1744-7909
Titre abrégé: J Integr Plant Biol
Pays: China (Republic : 1949- )
ID NLM: 101250502
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
02
08
2021
accepted:
04
10
2021
pubmed:
13
10
2021
medline:
5
4
2022
entrez:
12
10
2021
Statut:
ppublish
Résumé
Traditional Chinese medicine (TCM) belongs to the most elaborate and extensive systems of plant-based healing. The herb Northern Ban Lan (Isatis tinctoria) is famous for its antiviral and anti-inflammatory activity. Although numerous components isolated from I. tinctoria have been characterized so far, their modes of action have remained unclear. Here, we show that extracts from I. tinctoria exert anti-microtubular activity. Using time-lapse microscopy in living tobacco BY-2 (Nicotiana tabacum L. cv Bright Yellow 2) cells expressing green fluorescent protein-tubulin, we use activity-guided fractionation to screen out the biologically active compounds of I. tinctoria. Among 54 fractions obtained from either leaves or roots of I. tinctoria by methanol (MeOH/H
Substances chimiques
Glucosinolates
0
Indoles
0
glucobrassicin
EA6EH0IU89
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2058-2074Subventions
Organisme : This work was supported by fellowships from the China Scholarship Council to Pingyin Guan, Xin Zhu and Kunxi Zhang.
Informations de copyright
© 2021 The Authors. Journal of Integrative Plant Biology published by John Wiley & Sons Australia, Ltd on behalf of Institute of Botany, Chinese Academy of Sciences.
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