Mechanoreceptor synapses in the brainstem shape the central representation of touch.
LTMR
brainstem
disproportionate representation
homunculus
mechanoreceptor
neural activity
peripheral nervous system
piezo2
somatosensation
synaptic expansion
touch
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
28 10 2021
28 10 2021
Historique:
received:
03
02
2021
revised:
10
08
2021
accepted:
15
09
2021
pubmed:
13
10
2021
medline:
7
1
2022
entrez:
12
10
2021
Statut:
ppublish
Résumé
Mammals use glabrous (hairless) skin of their hands and feet to navigate and manipulate their environment. Cortical maps of the body surface across species contain disproportionately large numbers of neurons dedicated to glabrous skin sensation, in part reflecting a higher density of mechanoreceptors that innervate these skin regions. Here, we find that disproportionate representation of glabrous skin emerges over postnatal development at the first synapse between peripheral mechanoreceptors and their central targets in the brainstem. Mechanoreceptor synapses undergo developmental refinement that depends on proximity of their terminals to glabrous skin, such that those innervating glabrous skin make synaptic connections that expand their central representation. In mice incapable of sensing gentle touch, mechanoreceptors innervating glabrous skin still make more powerful synapses in the brainstem. We propose that the skin region a mechanoreceptor innervates controls the developmental refinement of its central synapses to shape the representation of touch in the brain.
Identifiants
pubmed: 34637701
pii: S0092-8674(21)01106-5
doi: 10.1016/j.cell.2021.09.023
pmc: PMC8556359
mid: NIHMS1742566
pii:
doi:
Substances chimiques
Ion Channels
0
Piezo2 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5608-5621.e18Subventions
Organisme : NICHD NIH HHS
ID : P50 HD105351
Pays : United States
Organisme : NINDS NIH HHS
ID : F32 NS106807
Pays : United States
Organisme : NINDS NIH HHS
ID : F32 NS095631
Pays : United States
Organisme : NINDS NIH HHS
ID : K99 NS119739
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS089521
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS097344
Pays : United States
Organisme : NIMH NIH HHS
ID : DP1 MH125776
Pays : United States
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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