The 'Yin and Yang' of Cancer Cell Growth and Mechanosensing.
ECM
anchorage-independence
mechanosensing
rigidity sensing
tumor stiffness
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
23 Sep 2021
23 Sep 2021
Historique:
received:
01
08
2021
revised:
07
09
2021
accepted:
16
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
14
10
2021
Statut:
epublish
Résumé
In cancer, two unique and seemingly contradictory behaviors are evident: on the one hand, tumors are typically stiffer than the tissues in which they grow, and this high stiffness promotes their malignant progression; on the other hand, cancer cells are anchorage-independent-namely, they can survive and grow in soft environments that do not support cell attachment. How can these two features be consolidated? Recent findings on the mechanisms by which cells test the mechanical properties of their environment provide insight into the role of aberrant mechanosensing in cancer progression. In this review article, we focus on the role of high stiffness on cancer progression, with particular emphasis on tumor growth; we discuss the mechanisms of mechanosensing and mechanotransduction, and their dysregulation in cancerous cells; and we propose that a 'yin and yang' type phenomenon exists in the mechanobiology of cancer, whereby a switch in the type of interaction with the extracellular matrix dictates the outcome of the cancer cells.
Identifiants
pubmed: 34638240
pii: cancers13194754
doi: 10.3390/cancers13194754
pmc: PMC8507527
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Israel Science Foundation
ID : 1738/17
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