HE4 as a Biomarker for Endometrial Cancer.
HE4
atypical endometrial hyperplasia
biomarker
endometrial cancer
human epididymis protein 4
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
23 Sep 2021
23 Sep 2021
Historique:
received:
03
08
2021
revised:
10
09
2021
accepted:
17
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
14
10
2021
Statut:
epublish
Résumé
There are currently no blood biomarkers in routine clinical use in endometrial carcinoma (EC). Human epididymis protein 4 (HE4) is a glycoprotein that is overexpressed in the serum of patients with EC, making it a good candidate for use as a diagnostic and/or prognostic biomarker. HE4 is correlated with poor prognostic factors, including stage, myometrial invasion and lymph node metastases, which means it could be used to guide decisions regarding the extent of surgery and need for adjuvant therapy. Serum HE4 has also shown promise for predicting responses to progestin therapy in early-stage EC. The use of algorithms and indices incorporating serum HE4 and other biomarkers, including clinical and imaging variables, is an area of increasing interest. Serum HE4 levels rise with age and renal dysfunction, which may affect the interpretation of results. This review covers the evidence supporting the use of HE4 as an EC biomarker for diagnosis, prognosis, recurrence monitoring, and prediction of therapy response. The evidence for combining serum HE4 with other biomarkers, including clinical and imaging variables, its value as a biomarker in other biofluids and potential challenges of its clinical use are also discussed.
Identifiants
pubmed: 34638250
pii: cancers13194764
doi: 10.3390/cancers13194764
pmc: PMC8507549
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Manchester Biomedical Research Centre
ID : IS-BRC-1215-20007
Organisme : National Institute for Health Research
ID : NIHR300650
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