Prediction of Early Distant Recurrence in Upfront Resectable Pancreatic Adenocarcinoma: A Multidisciplinary, Machine Learning-Based Approach.

X-ray computed tomography machine learning pancreatic adenocarcinoma prognosis radiomics

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
30 Sep 2021
Historique:
received: 30 08 2021
revised: 27 09 2021
accepted: 28 09 2021
entrez: 13 10 2021
pubmed: 14 10 2021
medline: 14 10 2021
Statut: epublish

Résumé

Despite careful selection, the recurrence rate after upfront surgery for pancreatic adenocarcinoma can be very high. We aimed to construct and validate a model for the prediction of early distant recurrence (<12 months from index surgery) after upfront pancreaticoduodenectomy. After exclusions, 147 patients were retrospectively enrolled. Preoperative clinical and radiological (CT-based) data were systematically evaluated; moreover, 182 radiomics features (RFs) were extracted. Most significant RFs were selected using minimum redundancy, robustness against delineation uncertainty and an original machine learning bootstrap-based method. Patients were split into training (

Identifiants

pubmed: 34638421
pii: cancers13194938
doi: 10.3390/cancers13194938
pmc: PMC8508250
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG23015

Références

Insights Imaging. 2020 Aug 12;11(1):91
pubmed: 32785796
Dig Liver Dis. 2009 May;41(5):325-7
pubmed: 19297258
Ann Surg. 2020 Oct 19;:
pubmed: 33086324
Eur Radiol. 2021 Sep;31(9):6879-6888
pubmed: 33665718
Br J Surg. 2019 Mar;106(4):342-354
pubmed: 30758855
Trends Microbiol. 2018 Oct;26(10):815-832
pubmed: 29843923
Cancers (Basel). 2021 Apr 13;13(8):
pubmed: 33924363
Dig Liver Dis. 2017 Feb;49(2):223-226
pubmed: 27931968
Pancreatology. 2015 Nov-Dec;15(6):674-80
pubmed: 26467797
Pancreas. 2020 May/Jun;49(5):634-641
pubmed: 32433400
Sci Rep. 2019 Mar 13;9(1):4329
pubmed: 30867443
Radiology. 2018 May;287(2):374-390
pubmed: 29668413
J Gastrointest Surg. 2019 May;23(5):990-996
pubmed: 30242645
Pancreatology. 2014 Nov-Dec;14(6):524-9
pubmed: 25287158
Ann Surg. 2019 Jun;269(6):1154-1162
pubmed: 31082915
Phys Med. 2019 Jan;57:41-46
pubmed: 30738530
Eur Radiol. 2021 May;31(5):3447-3467
pubmed: 33151391
J Clin Oncol. 2006 Jun 20;24(18):2897-902
pubmed: 16782929
Radiother Oncol. 2020 Dec;153:258-264
pubmed: 32681930
Radiology. 2020 May;295(2):328-338
pubmed: 32154773
BMC Med Imaging. 2017 Jun 19;17(1):38
pubmed: 28629416
J Gastrointest Surg. 2012 May;16(5):977-85
pubmed: 22411488
J Gastroenterol Hepatol. 2009 Dec;24(12):1869-75
pubmed: 19686409
Ann Surg. 2018 May;267(5):936-945
pubmed: 28338509
World J Surg. 2014 Nov;38(11):2960-6
pubmed: 24870390
Radiol Med. 2021 Jun;126(6):745-760
pubmed: 33523367
Radiology. 2020 Sep;296(3):541-551
pubmed: 32662759
JAMA Surg. 2015 Aug;150(8):701-10
pubmed: 26062046
J Gastrointest Oncol. 2012 Jun;3(2):105-19
pubmed: 22811878
Ann Surg Oncol. 2009 Dec;16(12):3316-22
pubmed: 19707831
Pancreatology. 2018 Jul;18(5):585-591
pubmed: 29866508
Updates Surg. 2021 Aug;73(4):1219-1229
pubmed: 34331677
Ann Intern Med. 2015 Jan 6;162(1):55-63
pubmed: 25560714
Phys Med. 2020 Aug;76:125-133
pubmed: 32673824
Eur Radiol. 2020 May;30(5):2513-2524
pubmed: 32006171
Br J Radiol. 2017 May;90(1073):20160403
pubmed: 28339284
Lancet Gastroenterol Hepatol. 2018 Jun;3(6):413-423
pubmed: 29625841
J Nucl Med. 2018 Feb;59(2):189-193
pubmed: 29175982
J Am Coll Surg. 2016 Jul;223(1):52-65
pubmed: 27049786
JAMA Surg. 2018 Dec 1;153(12):e183617
pubmed: 30285076
Sci Rep. 2019 Oct 30;9(1):15662
pubmed: 31666626
Gastroenterology. 2014 Jan;146(1):291-304.e1
pubmed: 24355035
J Clin Epidemiol. 1996 Dec;49(12):1373-9
pubmed: 8970487
Nat Rev Clin Oncol. 2017 Dec;14(12):749-762
pubmed: 28975929
Ann Surg. 2004 Aug;240(2):293-8
pubmed: 15273554

Auteurs

Diego Palumbo (D)

Department of Radiology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.

Martina Mori (M)

Department of Medical Physics, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Francesco Prato (F)

School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.

Stefano Crippa (S)

School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Giulio Belfiori (G)

School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Michele Reni (M)

School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Department of Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Junaid Mushtaq (J)

Department of Radiology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.

Francesca Aleotti (F)

School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Giorgia Guazzarotti (G)

Department of Radiology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Roberta Cao (R)

School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.

Stephanie Steidler (S)

Department of Radiology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Domenico Tamburrino (D)

Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Emiliano Spezi (E)

School of Engineering, Cardiff University, Cardiff CF24 3AA, UK.

Antonella Del Vecchio (A)

Department of Medical Physics, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Stefano Cascinu (S)

School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Department of Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Massimo Falconi (M)

School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Claudio Fiorino (C)

Department of Medical Physics, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Francesco De Cobelli (F)

Department of Radiology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.

Classifications MeSH