The Diverse Applications of Pancreatic Ductal Adenocarcinoma Organoids.
PDAC
cancer
coculture
drug screen
fibroblast
immune
microenvironment
organoid
patient derived
therapeutic
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
04 Oct 2021
04 Oct 2021
Historique:
received:
13
09
2021
accepted:
27
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
14
10
2021
Statut:
epublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies. While immortalized cancer cell lines and genetically engineered murine models have increased our understanding of PDAC tumorigenesis, they do not recapitulate inter- and intra-patient heterogeneity. PDAC patient derived organoid (PDO) biobanks have overcome this hurdle, and provide an opportunity for the high throughput screening of potential new therapies. This review provides a summary of the PDAC PDO biobanks established to date, and discusses how they have advanced our understanding of PDAC biology. Looking forward, the development of coculturing techniques for specific immune or stromal cell populations will enable a better understanding of the crosstalk that occurs within the tumor microenvironment, and the impact of this crosstalk on treatment response.
Identifiants
pubmed: 34638463
pii: cancers13194979
doi: 10.3390/cancers13194979
pmc: PMC8508245
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Health and Medical Research Council
ID : APP1098643
Organisme : Victorian Cancer Agency
ID : MCRF16009
Références
Br J Cancer. 2014 Aug 26;111(5):817-22
pubmed: 24755884
Surg Oncol Clin N Am. 2017 Oct;26(4):767-790
pubmed: 28923230
Cancers (Basel). 2020 Dec 17;12(12):
pubmed: 33348809
Gut. 2018 Mar;67(3):508-520
pubmed: 28073890
Trends Cancer. 2016 Apr;2(4):176-190
pubmed: 27135056
Cancer Res. 1986 Nov;46(11):5810-5
pubmed: 3019537
Nat Commun. 2019 Aug 8;10(1):3574
pubmed: 31395879
Histopathology. 2020 Jan;76(2):182-188
pubmed: 31433515
EBioMedicine. 2020 Jul;57:102858
pubmed: 32629389
Cancer Cell. 2011 Apr 12;19(4):441-55
pubmed: 21481787
Clin Cancer Res. 2006 Apr 15;12(8):2492-7
pubmed: 16638857
Front Oncol. 2020 May 15;10:553
pubmed: 32500020
Proc Natl Acad Sci U S A. 1990 May;87(10):4012-6
pubmed: 1692630
J Biotechnol. 2010 Jul 1;148(1):16-23
pubmed: 20083148
Arch Med Sci. 2018 Jun;14(4):910-919
pubmed: 30002710
Braz J Med Biol Res. 2013 Jul;46(7):634-42
pubmed: 23903680
Semin Radiat Oncol. 2015 Oct;25(4):273-80
pubmed: 26384275
Pancreas. 2004 Jan;28(1):38-44
pubmed: 14707728
Cancer. 1981 Mar 15;47(6 Suppl):1490-6
pubmed: 6791803
Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13438-43
pubmed: 20624967
Methods Mol Biol. 2007;380:253-69
pubmed: 17876098
Development. 1996 Mar;122(3):983-95
pubmed: 8631275
Clin Cancer Res. 2003 Sep 15;9(11):4227-39
pubmed: 14519650
J Clin Oncol. 2010 Aug 1;28(22):3617-22
pubmed: 20606091
Biomed Res Int. 2017;2017:2646148
pubmed: 29379795
Gastroenterology. 2011 Apr;140(4):1303-1313.e1-3
pubmed: 21199651
Cell Mol Gastroenterol Hepatol. 2020;9(1):105-119
pubmed: 31526907
J Hepatobiliary Pancreat Surg. 2007;14(3):224-32
pubmed: 17520196
J Clin Oncol. 2010 Aug 1;28(22):3605-10
pubmed: 20606093
J Transl Med. 2016 Feb 04;14:38
pubmed: 26847768
Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20212-7
pubmed: 24277834
Sci Rep. 2019 Aug 22;9(1):12286
pubmed: 31439856
Nature. 2020 Jan;577(7791):566-571
pubmed: 31915377
Cancer Discov. 2015 Jan;5(1):52-63
pubmed: 25361845
J Pathol. 2016 Jan;238(2):197-204
pubmed: 26419819
PLoS Comput Biol. 2019 Jan 10;15(1):e1006596
pubmed: 30629588
Cell Rep. 2017 Nov 28;21(9):2458-2470
pubmed: 29186684
Biomaterials. 2016 Nov;108:129-42
pubmed: 27627810
Biochem Soc Trans. 2016 Aug 15;44(4):1117-34
pubmed: 27528760
Cancer Cell. 2014 May 12;25(5):621-37
pubmed: 24823639
Gut. 2019 Jan;68(1):159-171
pubmed: 30177543
Theranostics. 2019 Jan 1;9(2):324-336
pubmed: 30809277
PLoS One. 2013 Sep 10;8(9):e73345
pubmed: 24039920
J Clin Oncol. 2017 Jul 10;35(20):2324-2328
pubmed: 28398845
World J Gastroenterol. 2018 May 21;24(19):2047-2060
pubmed: 29785074
Cancer Discov. 2014 Sep;4(9):998-1013
pubmed: 25185190
Elife. 2016 Feb 23;5:
pubmed: 26902720
J Exp Med. 2017 Mar 6;214(3):579-596
pubmed: 28232471
Gastrointest Endosc. 2018 Jun;87(6):1474-1480
pubmed: 29325707
Am J Pathol. 2019 Jan;189(1):9-21
pubmed: 30558727
Cancer Cell. 2005 May;7(5):469-83
pubmed: 15894267
J Surg Oncol. 2017 Jul;116(1):55-62
pubmed: 28628715
Gastroenterology. 2018 Dec;155(6):1999-2013.e3
pubmed: 30165049
J Clin Oncol. 2007 May 20;25(15):1960-6
pubmed: 17452677
Nat Genet. 2020 Feb;52(2):231-240
pubmed: 31932696
Lancet. 2017 Mar 11;389(10073):1011-1024
pubmed: 28129987
Gastroenterology. 2010 Aug;139(2):586-97, 597.e1-6
pubmed: 20452353
Stem Cell Res. 2014 Sep;13(2):275-83
pubmed: 25151611
Sci Rep. 2017 Feb 01;7:41064
pubmed: 28145465
N Engl J Med. 2011 May 12;364(19):1817-25
pubmed: 21561347
Mol Cancer Res. 2016 Feb;14(2):216-27
pubmed: 26609108
Cancer Discov. 2019 Aug;9(8):1102-1123
pubmed: 31197017
Nature. 2015 Feb 26;518(7540):495-501
pubmed: 25719666
J Natl Cancer Inst. 1977 Jul;59(1):221-6
pubmed: 327080
Nature. 2015 Nov 26;527(7579):525-530
pubmed: 26560028
Cell Oncol (Dordr). 2011 Dec;34(6):511-21
pubmed: 21681527
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
Virchows Arch B Cell Pathol. 1975 Dec 19;19(4):325-36
pubmed: 813379
Nat Commun. 2016 Sep 15;7:12819
pubmed: 27628423
Front Cell Dev Biol. 2020 Apr 28;8:308
pubmed: 32411709
Proc Natl Acad Sci U S A. 2019 Dec 9;:
pubmed: 31818951
Mol Cancer Res. 2019 Jan;17(1):70-83
pubmed: 30171177
Int J Cancer. 1977 Jan;19(1):128-35
pubmed: 832918
Nature. 2016 Mar 3;531(7592):47-52
pubmed: 26909576
Cancer Discov. 2020 Oct;10(10):1566-1589
pubmed: 32703770
Pancreas. 2010 May;39(4):425-35
pubmed: 20418756
Cancer J. 2015 Jul-Aug;21(4):250-3
pubmed: 26222075
Cell. 2015 Jan 15;160(1-2):324-38
pubmed: 25557080
Clin Cancer Res. 2011 Sep 1;17(17):5793-800
pubmed: 21742805
Am J Pathol. 2015 May;185(5):1297-303
pubmed: 25770474
Cancer Res. 2014 Jun 1;74(11):2913-21
pubmed: 24840647
Exp Cell Res. 2017 Aug 15;357(2):299-309
pubmed: 28571915
Nat Cell Biol. 2017 May;19(5):518-529
pubmed: 28414315
Cancer Cell. 2007 Mar;11(3):229-43
pubmed: 17349581
Clin Cancer Res. 2019 Apr 1;25(7):2194-2205
pubmed: 30385653
Nat Rev Cancer. 2016 Sep;16(9):553-65
pubmed: 27444064
Dev Cell. 2018 Jun 18;45(6):681-695.e4
pubmed: 29920274
Cell. 2016 Aug 11;166(4):963-976
pubmed: 27477511
Cancer Invest. 1986;4(1):15-23
pubmed: 3754176
Cancer Res. 2013 Oct 15;73(20):6359-74
pubmed: 24097820
Nature. 2019 Feb;566(7742):126-130
pubmed: 30700911
Nat Genet. 2015 Oct;47(10):1168-78
pubmed: 26343385
Clin Gastroenterol Hepatol. 2008 Oct;6(10):1155-61
pubmed: 18639493
Cell. 2011 Jan 7;144(1):27-40
pubmed: 21215367
In Vitro Cell Dev Biol. 1988 Dec;24(12):1179-87
pubmed: 3264833
Cancer J. 2017 Nov/Dec;23(6):321-325
pubmed: 29189327
Curr Protoc Pharmacol. 2016 Jun 01;73:14.39.1-14.39.20
pubmed: 27248578
In Vitro Cell Dev Biol Anim. 1993 Jul;29A(7):574-84
pubmed: 8354666
Pancreas. 2016 Jul;45(6):863-9
pubmed: 26495796
J Natl Cancer Inst. 1979 Feb;62(2):225-30
pubmed: 283258
Clin Cancer Res. 2018 Mar 15;24(6):1344-1354
pubmed: 29288237
Oncogene. 2012 Oct 11;31(41):4484-9
pubmed: 22158044
Oncotarget. 2016 Sep 20;7(38):62533-62546
pubmed: 27613834
Development. 2013 Nov;140(21):4452-62
pubmed: 24130330
Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5947-52
pubmed: 16585505
Nucleic Acids Res. 2011 Oct;39(18):7900-7
pubmed: 21724610
Ann Oncol. 2019 Sep 1;30(9):1472-1478
pubmed: 31250894
United European Gastroenterol J. 2020 Jun;8(5):594-606
pubmed: 32213029
Clin Cancer Res. 2018 Apr 1;24(7):1734-1747
pubmed: 29330203
Cold Spring Harb Protoc. 2016 Jan 04;2016(1):pdb.prot078352
pubmed: 26729901
PLoS One. 2017 Jul 27;12(7):e0182039
pubmed: 28750018
Ann Surg Oncol. 2009 Apr;16(4):836-47
pubmed: 19194760
Cancer Res. 1982 Feb;42(2):601-8
pubmed: 7034925
Science. 2019 Jun 21;364(6446):1156-1162
pubmed: 31221853
EMBO J. 2013 Oct 16;32(20):2708-21
pubmed: 24045232
Cell Stem Cell. 2018 Mar 1;22(3):454-467.e6
pubmed: 29337182
BMC Cancer. 2018 Mar 27;18(1):335
pubmed: 29587663
Cancer Discov. 2018 Sep;8(9):1112-1129
pubmed: 29853643
N Engl J Med. 2019 Jul 25;381(4):317-327
pubmed: 31157963
J Transl Med. 2015 Apr 11;13:115
pubmed: 25884700
In Vitro. 1982 Jan;18(1):24-34
pubmed: 7182348
Development. 2015 Sep 15;142(18):3113-25
pubmed: 26395140
Nat Med. 2014 Jul;20(7):769-77
pubmed: 24859528
Cancers (Basel). 2018 Sep 06;10(9):
pubmed: 30200666
Cancer Res. 2020 Jul 1;80(13):2804-2817
pubmed: 32376602
Nat Med. 2011 Apr;17(4):500-3
pubmed: 21460848
Cancer Res Treat. 2018 Jan;50(1):1-10
pubmed: 28903551
Cell Stem Cell. 2018 Dec 6;23(6):882-897.e11
pubmed: 30344100
Med Mol Morphol. 2010 Dec;43(4):211-7
pubmed: 21267697
Cancer Discov. 2015 Oct;5(10):1086-97
pubmed: 26209539
J Exp Clin Cancer Res. 2018 Jan 12;37(1):4
pubmed: 29329547
PLoS One. 2017 Aug 30;12(8):e0182855
pubmed: 28854237
Arch Pathol Lab Med. 2009 Mar;133(3):413-22
pubmed: 19260747
Sci Rep. 2017 Sep 5;7(1):10428
pubmed: 28874803
Cancer Cell. 2017 Aug 14;32(2):185-203.e13
pubmed: 28810144
Biomaterials. 2019 Nov;222:119421
pubmed: 31494503
Cell. 2012 Jan 20;148(1-2):349-61
pubmed: 22265420
Tissue Eng Part C Methods. 2016 Apr;22(4):312-21
pubmed: 26830354
Nature. 2012 Nov 15;491(7424):399-405
pubmed: 23103869
Gastroenterology. 2015 Jul;149(1):201-10
pubmed: 25888329
Cell. 2017 Aug 24;170(5):875-888.e20
pubmed: 28757253
In Vivo. 2018 May-Jun;32(3):653-657
pubmed: 29695574
Genes Dev. 2003 Dec 15;17(24):3112-26
pubmed: 14681207
Cancer Res. 2007 Oct 1;67(19):9518-27
pubmed: 17909062
Mol Cancer Ther. 2011 Oct;10(10):1993-9
pubmed: 21862683
Ann Oncol. 2012 Nov;23(11):2799-2805
pubmed: 22771827
Cell. 2016 Feb 25;164(5):1015-30
pubmed: 26898331
N Engl J Med. 2014 Nov 27;371(22):2140-1
pubmed: 25427123
Oncotarget. 2018 Feb 6;9(16):13009-13022
pubmed: 29560127
Nat Med. 2019 Oct;25(10):1607-1614
pubmed: 31591597
Pancreas. 2016 Jul;45(6):908-14
pubmed: 26745860
Int J Cancer. 1975 May 15;15(5):741-7
pubmed: 1140870
N Engl J Med. 2018 Dec 20;379(25):2395-2406
pubmed: 30575490
Nature. 2019 May;569(7754):131-135
pubmed: 30996350
Am J Pathol. 1982 Feb;106(2):250-60
pubmed: 6278935
Invest New Drugs. 2018 Aug;36(4):732-741
pubmed: 29616439
Gut. 2018 Dec;67(12):2142-2155
pubmed: 29080858
Cancer Cell. 2011 Apr 12;19(4):456-69
pubmed: 21481788
Sci Rep. 2016 Jul 01;6:28951
pubmed: 27364600
Pancreas. 2004 Oct;29(3):179-87
pubmed: 15367883
Clin Cancer Res. 2006 Aug 1;12(15):4652-61
pubmed: 16899615
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
J Clin Oncol. 2020 Aug 5;:JCO2001364
pubmed: 32755482
Cancer Lett. 2018 Jul 1;425:65-77
pubmed: 29580808
J Proteome Res. 2019 Jul 5;18(7):2826-2834
pubmed: 31120258
BMC Cancer. 2020 May 13;20(1):417
pubmed: 32404074
Cell. 2018 Dec 13;175(7):1972-1988.e16
pubmed: 30550791
In Vitro Cell Dev Biol Anim. 1994 Mar;30A(3):151-61
pubmed: 25939163
Acta Oncol. 2018 Dec;57(12):1655-1662
pubmed: 30264642
BMC Cancer. 2013 Feb 27;13:95
pubmed: 23446043
Nat Med. 2016 Mar;22(3):278-87
pubmed: 26855150
Clin Cancer Res. 2019 Nov 15;25(22):6742-6755
pubmed: 31492749
Front Biosci (Elite Ed). 2012 Jan 01;4:1871-87
pubmed: 22202004
Mol Cancer Ther. 2011 Aug;10(8):1311-6
pubmed: 21673092
Gut. 2020 Feb;69(2):317-328
pubmed: 31201285
Gastroenterology. 2014 Jun;146(7):1784-94.e6
pubmed: 24607504
N Engl J Med. 2013 Oct 31;369(18):1691-703
pubmed: 24131140
Cell. 2018 Aug 9;174(4):856-869.e17
pubmed: 30096312
Nat Med. 2015 Nov;21(11):1364-71
pubmed: 26501191
Science. 2018 Feb 23;359(6378):920-926
pubmed: 29472484
Nature. 2016 Nov 24;539(7630):560-564
pubmed: 27851739
Intern Med J. 2020 Oct 11;:
pubmed: 33040452