RBL1/p107 Expression Levels Are Modulated by Multiple Signaling Pathways.
AKT
CaMK
RBL1/p107
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
08 Oct 2021
08 Oct 2021
Historique:
received:
20
07
2021
revised:
29
09
2021
accepted:
02
10
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
14
10
2021
Statut:
epublish
Résumé
The members of the retinoblastoma (RB) protein family, RB1/p105, retinoblastoma-like (RBL)1/p107 and RBL2/p130 are critical modulators of the cell cycle and their dysregulation has been associated with tumor initiation and progression. The activity of RB proteins is regulated by numerous pathways including oncogenic signaling, but the molecular mechanisms of these functional interactions are not fully defined. We previously demonstrated that RBL2/p130 is a direct target of AKT and it is a key mediator of the apoptotic process induced by AKT inhibition. Here we demonstrated that RBL1/p107 levels are only minorly modulated by the AKT signaling pathway. In contrast, we discovered that RBL1/p107 levels are regulated by multiple pathways linked directly or indirectly to Ca
Identifiants
pubmed: 34638509
pii: cancers13195025
doi: 10.3390/cancers13195025
pmc: PMC8507926
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Sbarro Health Research Organization
ID : Sbarro Health Research Organization
Références
Cell Cycle. 2004 Oct;3(10):1320-30
pubmed: 15467457
Nat Rev Cancer. 2013 Aug;13(8):585-95
pubmed: 23842645
Oncogene. 2019 Jun;38(25):4962-4976
pubmed: 30833638
Cancer Res. 2005 Jun 15;65(12):5408-16
pubmed: 15958590
Oncogene. 1999 Mar 11;18(10):1789-96
pubmed: 10086333
JCI Insight. 2019 Nov 14;4(22):
pubmed: 31613797
J Biol Chem. 1998 Nov 27;273(48):31880-9
pubmed: 9822657
Science. 1992 May 22;256(5060):1199-202
pubmed: 1317063
Biochim Biophys Acta. 2014 Dec;1846(2):342-52
pubmed: 25109892
Immunity. 2021 Feb 9;54(2):367-386.e8
pubmed: 33567262
Biochem J. 1998 Aug 1;333 ( Pt 3):645-54
pubmed: 9677324
J Biochem. 1997 Aug;122(2):337-43
pubmed: 9378711
Cell Cycle. 2011 Feb 15;10(4):631-9
pubmed: 21301225
Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G412-9
pubmed: 14592948
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Nat Struct Biol. 2002 Apr;9(4):239-41
pubmed: 11914728
Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):513-521
pubmed: 31871154
Chem Biol Interact. 2010 Dec 5;188(3):546-52
pubmed: 20832391
Cell Mol Life Sci. 2008 Sep;65(17):2637-57
pubmed: 18463790
Mol Cell Biol. 2013 Aug;33(16):3330-42
pubmed: 23775125
Nat Rev Cancer. 2008 Sep;8(9):671-82
pubmed: 18650841
Nucleic Acids Res. 2019 Dec 2;47(21):11197-11208
pubmed: 31667499
Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22300-22306
pubmed: 31611390
Exp Cell Res. 1998 May 1;240(2):218-27
pubmed: 9596994
J Biol Chem. 2003 May 16;278(20):18597-605
pubmed: 12637513
J Biochem. 1997 Nov;122(5):897-900
pubmed: 9443802
Science. 1993 Dec 24;262(5142):2050-4
pubmed: 8266103
J Clin Invest. 2021 Feb 15;131(4):
pubmed: 33444292
Nat Rev Mol Cell Biol. 2013 May;14(5):297-306
pubmed: 23594950
Mol Cell Biol. 2013 Aug;33(15):2865-78
pubmed: 23716589
EMBO J. 1995 Aug 1;14(15):3679-86
pubmed: 7641687
Mol Cell Biol. 2002 Apr;22(7):2242-54
pubmed: 11884610
J Biol Chem. 2002 Jul 26;277(30):26741-52
pubmed: 12006580
Int J Mol Med. 1999 Nov;4(5):487-92
pubmed: 10534570
Mol Cell Biol. 2009 Aug;29(15):4188-200
pubmed: 19487459
Mol Cell. 2016 Oct 6;64(1):25-36
pubmed: 27642049
Cell Growth Differ. 1999 Nov;10(11):721-8
pubmed: 10593648
Pharmaceuticals (Basel). 2019 Jan 07;12(1):
pubmed: 30621060
Cell. 2017 Feb 23;168(5):890-903.e15
pubmed: 28162770
Gastroenterology. 2014 Feb;146(2):520-9
pubmed: 24512911
Oncogene. 2005 Apr 18;24(17):2796-809
pubmed: 15838516
PLoS One. 2009 Aug 06;4(8):e6529
pubmed: 19657394
Cell Div. 2012 Mar 14;7(1):10
pubmed: 22417103
Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2110-5
pubmed: 10051603
Cancer Cell. 2018 Mar 12;33(3):450-462.e10
pubmed: 29533785
Bone. 2014 Dec;69:47-54
pubmed: 25182511
J Biol Chem. 2004 Apr 9;279(15):15411-9
pubmed: 14754892
Proc Natl Acad Sci U S A. 2017 May 9;114(19):4942-4947
pubmed: 28439018
Genes Dev. 1997 Jun 1;11(11):1447-63
pubmed: 9192872
Stem Cells. 2017 May;35(5):1378-1391
pubmed: 28233396
Nature. 2010 Dec 16;468(7326):968-72
pubmed: 21107320
J Biol Chem. 2015 Jun 5;290(23):14462-75
pubmed: 25903125
Mol Cell. 2019 May 16;74(4):758-770.e4
pubmed: 30982746
Genes Dev. 1995 Jun 1;9(11):1340-53
pubmed: 7797074
Cancer Cell. 2011 Nov 15;20(5):620-34
pubmed: 22094256
J Cell Physiol. 2013 Mar;228(3):525-35
pubmed: 22886479
J Cell Physiol. 2001 Oct;189(1):34-44
pubmed: 11573202
Nat Rev Cancer. 2011 May;11(5):364-74
pubmed: 21508973
Nature. 2008 Nov 20;456(7220):409-12
pubmed: 19020623
Lab Invest. 2007 Sep;87(9):938-50
pubmed: 17632540
Cell Growth Differ. 1995 Oct;6(10):1287-98
pubmed: 8845306
Cell Signal. 2010 May;22(5):759-69
pubmed: 20060891
PLoS Genet. 2010 Jun 24;6(6):e1001003
pubmed: 20585628
Oncogene. 2018 Jul;37(27):3657-3671
pubmed: 29606701
Cell Calcium. 2002 Jul;32(1):31-8
pubmed: 12127060
Genes Dev. 1996 Jul 1;10(13):1621-32
pubmed: 8682293
Cell Signal. 2015 Feb;27(2):204-14
pubmed: 25446257
J Biol Chem. 2010 Sep 24;285(39):29863-73
pubmed: 20663872
Cell Div. 2010 Apr 02;5:9
pubmed: 20359370