Targeting the RNA-Binding Protein HuR as Potential Thera-Peutic Approach for Neurological Disorders: Focus on Amyo-Trophic Lateral Sclerosis (ALS), Spinal Muscle Atrophy (SMA) and Multiple Sclerosis.
ELAV/Hu
HuR
RNA-binding proteins (RPBs)
demyelination
glia
neurodegenerative disease
neuroinflammation
neuroprotection
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Sep 2021
27 Sep 2021
Historique:
received:
31
08
2021
revised:
22
09
2021
accepted:
24
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
28
10
2021
Statut:
epublish
Résumé
The importance of precise co- and post-transcriptional processing of RNA in the regulation of gene expression has become increasingly clear. RNA-binding proteins (RBPs) are a class of proteins that bind single- or double-chain RNA, with different affinities and selectivity, thus regulating the various functions of RNA and the fate of the cells themselves. ELAV (embryonic lethal/abnormal visual system)/Hu proteins represent an important family of RBPs and play a key role in the fate of newly transcribed mRNA. ELAV proteins bind AU-rich element (ARE)-containing transcripts, which are usually present on the mRNA of proteins such as cytokines, growth factors, and other proteins involved in neuronal differentiation and maintenance. In this review, we focused on a member of ELAV/Hu proteins, HuR, and its role in the development of neurodegenerative disorders, with a particular focus on demyelinating diseases.
Identifiants
pubmed: 34638733
pii: ijms221910394
doi: 10.3390/ijms221910394
pmc: PMC8508990
pii:
doi:
Substances chimiques
Cytokines
0
ELAV-Like Protein 1
0
ELAVL1 protein, human
0
RNA, Messenger
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondazione Italiana Sclerosi Multipla
ID : 2019/R-Single/036 (EC)
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