Characterization of Human Medullary Thyroid Carcinoma Glycosphingolipids Identifies Potential Cancer Markers.
Forssman antigen
Lewis y antigen
glycosphingolipid characterization
human medullary thyroid cancer marker
mass spectrometry
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Sep 2021
28 Sep 2021
Historique:
received:
07
09
2021
revised:
23
09
2021
accepted:
23
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
9
11
2021
Statut:
epublish
Résumé
Medullary thyroid carcinoma (MTC) accounts for only 1-2% of thyroid cancers; however, metastatic MTC is a mortal disease with no cure. In this study, glycosphingolipids were isolated from human MTCs and characterized by mass spectrometry and binding of carbohydrate recognizing ligands. The tissue distribution of selected compounds was investigated by immunohistochemistry. The amount of acid glycosphingolipids in the MTCs was higher than in the normal thyroid glands. The major acid glycosphingolipid was the GD3 ganglioside. Sulfatide and the gangliosides GM3 and GD1a were also present. The majority of the complex non-acid glycosphingolipids had type 2 (Galβ4GlcNAc) core chains, i.e., the neolactotetraosylceramide, the Le
Identifiants
pubmed: 34638800
pii: ijms221910463
doi: 10.3390/ijms221910463
pmc: PMC8509059
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Glycosphingolipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Swedish Cancer Foundation
ID : 20 0759 PjF 01 H
Organisme : Lisa and Johan Grönbergs Foundation
Organisme : Anna-Lisa och Bror Björnsson Stiftelse
Organisme : Gustafsson Foundation
Organisme : Eriksson Foundation
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