Cyclodextrins Allow the Combination of Incompatible Vancomycin and Ceftazidime into an Ophthalmic Formulation for the Treatment of Bacterial Keratitis.
bacterial keratitis
ceftazidime
cyclodextrins
design of experiments
nuclear magnetic resonance
ophthalmic solution
vancomycin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Sep 2021
29 Sep 2021
Historique:
received:
29
07
2021
revised:
24
09
2021
accepted:
27
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
28
10
2021
Statut:
epublish
Résumé
Ceftazidime (CZ) and vancomycin (VA) are two antibiotics used to treat bacterial keratitis. Due to their physical incompatibility (formation of a precipitate), it is not currently possible to associate both molecules in a single container for ophthalmic administration. We firstly characterized the incompatibility then investigated if 2-hydroxypropyl-beta (HPβCD) and 2-hydroxypropyl-gamma cyclodextrins (HPγCD) could prevent this incompatibility. The impact of pH on the precipitation phenomena was investigated by analysing the supernatant solution of the mixture using high performance liquid chromatography. A characterization of the inclusion of CZ with HPγCD using
Identifiants
pubmed: 34638878
pii: ijms221910538
doi: 10.3390/ijms221910538
pmc: PMC8508691
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
gamma-Cyclodextrins
0
hydroxypropyl-gamma-cyclodextrin
0
Vancomycin
6Q205EH1VU
Ceftazidime
9M416Z9QNR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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