Involvement of Microglia in Neurodegenerative Diseases: Beneficial Effects of Docosahexahenoic Acid (DHA) Supplied by Food or Combined with Nanoparticles.
Animals
Apoptosis
/ drug effects
Blood-Brain Barrier
/ metabolism
Dietary Supplements
Disease Models, Animal
Docosahexaenoic Acids
/ administration & dosage
Drug Delivery Systems
/ methods
Humans
Inflammation
/ diet therapy
Microglia
/ metabolism
Nanoparticles
/ chemistry
Neurodegenerative Diseases
/ diet therapy
Oxidative Stress
/ drug effects
Protective Agents
/ administration & dosage
Treatment Outcome
docosahexaenoic acid
inflammation
microglia
nanomedicine
neurodegenerative disease
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Sep 2021
30 Sep 2021
Historique:
received:
02
09
2021
revised:
24
09
2021
accepted:
27
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
9
11
2021
Statut:
epublish
Résumé
Neurodegenerative diseases represent a major public health issue and require better therapeutic management. The treatments developed mainly target neuronal activity. However, an inflammatory component must be considered, and microglia may constitute an important therapeutic target. Given the difficulty in developing molecules that can cross the blood-brain barrier, the use of food-derived molecules may be an interesting therapeutic avenue. Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid (22:6 omega-3), has an inhibitory action on cell death and oxidative stress induced in the microglia. It also acts on the inflammatory activity of microglia. These data obtained in vitro or on animal models are corroborated by clinical trials showing a protective effect of DHA. Whereas DHA crosses the blood-brain barrier, nutritional intake lacks specificity at both the tissue and cellular level. Nanomedicine offers new tools which favor the delivery of DHA at the cerebral level, especially in microglial cells. Because of the biological activities of DHA and the associated nanotargeting techniques, DHA represents a therapeutic molecule of interest for the treatment of neurodegenerative diseases.
Identifiants
pubmed: 34638979
pii: ijms221910639
doi: 10.3390/ijms221910639
pmc: PMC8508587
pii:
doi:
Substances chimiques
Protective Agents
0
Docosahexaenoic Acids
25167-62-8
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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