Non-Coding RNAs in Preeclampsia-Molecular Mechanisms and Diagnostic Potential.
Biomarkers
/ blood
Cell Differentiation
/ genetics
Cell Movement
/ genetics
Cell Proliferation
/ genetics
Chromosomes, Human, Pair 19
/ genetics
Circulating MicroRNA
/ blood
Female
Gene Expression Regulation, Developmental
Humans
Pre-Eclampsia
/ blood
Pregnancy
RNA, Long Noncoding
/ blood
Transcriptome
Trophoblasts
/ metabolism
biomarkers
lncRNA
microRNA
preeclampsia
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Sep 2021
30 Sep 2021
Historique:
received:
31
08
2021
revised:
25
09
2021
accepted:
26
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
9
11
2021
Statut:
epublish
Résumé
Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Defects in trophoblast invasion, differentiation of extravillous trophoblasts and spiral artery remodeling are key factors in PE development. Currently there are no predictive biomarkers clinically available for PE. Recent technological advancements empowered transcriptome exploration and led to the discovery of numerous non-coding RNA species of which microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are the most investigated. They are implicated in the regulation of numerous cellular functions, and as such are being extensively explored as potential biomarkers for various diseases. Altered expression of numerous lncRNAs and miRNAs in placenta has been related to pathophysiological processes that occur in preeclampsia. In the following text we offer summary of the latest knowledge of the molecular mechanism by which lnRNAs and miRNAs (focusing on the chromosome 19 miRNA cluster (C19MC)) contribute to pathophysiology of PE development and their potential utility as biomarkers of PE, with special focus on sample selection and techniques for the quantification of lncRNAs and miRNAs in maternal circulation.
Identifiants
pubmed: 34638993
pii: ijms221910652
doi: 10.3390/ijms221910652
pmc: PMC8508896
pii:
doi:
Substances chimiques
Biomarkers
0
Circulating MicroRNA
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
ID : 175035
Organisme : Labena ltd.
ID : Labena Grant Challenge 2020
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