Skin Barrier Dysregulation in Psoriasis.
environmental factors
genetic aberration
immune cells
keratinocyte
psoriasis
skin barrier
treatment
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Oct 2021
07 Oct 2021
Historique:
received:
19
09
2021
revised:
01
10
2021
accepted:
05
10
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
26
10
2021
Statut:
epublish
Résumé
The skin barrier is broadly composed of two elements-a physical barrier mostly localised in the epidermis, and an immune barrier localised in both the dermis and epidermis. These two systems interact cooperatively to maintain skin homeostasis and overall human health. However, if dysregulated, several skin diseases may arise. Psoriasis is one of the most prevalent skin diseases associated with disrupted barrier function. It is characterised by the formation of psoriatic lesions, the aberrant differentiation and proliferation of keratinocytes, and excessive inflammation. In this review, we summarize recent discoveries in disease pathogenesis, including the contribution of keratinocytes, immune cells, genetic and environmental factors, and how they advance current and future treatments.
Identifiants
pubmed: 34639182
pii: ijms221910841
doi: 10.3390/ijms221910841
pmc: PMC8509518
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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