Contributing to Understand the Crosstalk between Brain and Periphery in Methylmercury Intoxication: Neurotoxicity and Extracellular Vesicles.
CNS
MeHg
S100b
exosomes
exposure
mercury
pollutant
pollution
qPCR
real time
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Oct 2021
07 Oct 2021
Historique:
received:
30
08
2021
revised:
04
10
2021
accepted:
05
10
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
26
10
2021
Statut:
epublish
Résumé
Human exposure to methylmercury (MeHg) is currently high in regions such as the Amazon. Understanding the molecular changes associated with MeHg-induced neurotoxicity and the crosstalk with the periphery is essential to support early diagnoses. This work aimed to evaluate cellular and molecular changes associated with behavioral alterations in MeHg acute exposure and the possible changes in extracellular vesicles (EVs) number and S100β content. Adults male Wistar rats were orally treated with 5 mg/kg for four days. Behavioral performance, molecular and histological changes in the cerebellum, and plasma EVs were assessed. MeHg-intoxicated animals performed significantly worse in behavioral tests. MeHg increased the number of GFAP+ cells and GFAP and S100β mRNA expression in the cerebellum but no change in NeuN+ or IBA-1+ cells number was detected. The number of exosomes isolated from plasma were decreased by the metal. S100B mRNA was detected in circulating plasma EVs cargo in MeHg exposure. Though preliminary, our results suggest astrocytic reactivity is displaying a protective role once there was no neuronal death. Interestingly, the reduction in exosomes number could be a new mechanism associated with MeHg-induced neurotoxicity and plasma EVs could represent a source of future biomarkers in MeHg intoxication.
Identifiants
pubmed: 34639196
pii: ijms221910855
doi: 10.3390/ijms221910855
pmc: PMC8509412
pii:
doi:
Substances chimiques
Environmental Pollutants
0
Methylmercury Compounds
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 307564/2017-7
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 27724/2018-2
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 88887.200500/2018-00
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 88881.172137/2018-01
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