Exosomes and Brain Metastases: A Review on Their Role and Potential Applications.
blood–brain barrier
brain metastases
drug delivery system
exosomes
metastatic cancer
pre-metastatic niche
tumor microenvironment
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Oct 2021
08 Oct 2021
Historique:
received:
30
07
2021
revised:
26
09
2021
accepted:
28
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
3
11
2021
Statut:
epublish
Résumé
Brain metastases (BM) are a frequent complication in patients with advanced stages of cancer, associated with impairment of the neurological function, quality of life, prognosis, and survival. BM treatment consists of a combination of the available cancer therapies, such as surgery, radiotherapy, chemotherapy, immunotherapy and targeted therapies. Even so, cancer patients with BM are still linked to poor prognosis, with overall survival being reported as 12 months or less. Intercellular communication has a pivotal role in the development of metastases, therefore, it has been extensively studied not only to better understand the metastization process, but also to further develop new therapeutic strategies. Exosomes have emerged as key players in intercellular communication being potential therapeutic targets, drug delivery systems (DDS) or biomarkers. In this Review, we focus on the role of these extracellular vesicles (EVs) in BM formation and their promising application in the development of new BM therapeutic strategies.
Identifiants
pubmed: 34639239
pii: ijms221910899
doi: 10.3390/ijms221910899
pmc: PMC8509735
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação para a Ciência e a Tecnologia
ID : PD/BD/135046/2017
Organisme : Fundação para a Ciência e a Tecnologia
ID : PTDC/BIA-BQM/5027/2020
Organisme : Fundação para a Ciência e a Tecnologia
ID : DL 57/2016/CP1451/CT0023
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