Long-Term Outcome in Systemic Lupus Erythematosus; Knowledge from Population-Based Cohorts.
Systemic Lupus Erythematosus
cancer
end-stage renal disease
epidemiology
mortality
outcome
survival
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
22 Sep 2021
22 Sep 2021
Historique:
received:
02
08
2021
revised:
06
09
2021
accepted:
13
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
14
10
2021
Statut:
epublish
Résumé
Accurate knowledge of outcomes in Systemic Lupus Erythematosus (SLE) is crucial to understanding the true burden of the disease. The main objective of this systematic review was to gather all population-based studies on mortality, end-stage renal disease (ESRD) and cancer in SLE. We performed a systematic literature search in two electronic databases (MEDLINE and Embase) to identify all population-based articles on SLE and survival, mortality, ESRD and cancer. The SLE diagnosis had to be verified. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA). We included 40/1041 articles on mortality (27), ESRD (11) and cancer (3), of which six were defined as inception studies. In the total SLE cohort, the standardized mortality ratio ranged from 1.9 to 4.6. Cardiovascular disease was the most frequent cause of death in studies with follow-up times over 15 years. SLE progressed to ESRD in 5-11% of all SLE patients. There are no data supporting increased cancer incidence from population-based inception cohorts. There is a need for more population-based studies on outcomes of SLE, especially inception studies, with the use of control groups and follow-up times over 15 years.
Sections du résumé
BACKGROUND
BACKGROUND
Accurate knowledge of outcomes in Systemic Lupus Erythematosus (SLE) is crucial to understanding the true burden of the disease. The main objective of this systematic review was to gather all population-based studies on mortality, end-stage renal disease (ESRD) and cancer in SLE.
METHOD
METHODS
We performed a systematic literature search in two electronic databases (MEDLINE and Embase) to identify all population-based articles on SLE and survival, mortality, ESRD and cancer. The SLE diagnosis had to be verified. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA).
RESULTS
RESULTS
We included 40/1041 articles on mortality (27), ESRD (11) and cancer (3), of which six were defined as inception studies. In the total SLE cohort, the standardized mortality ratio ranged from 1.9 to 4.6. Cardiovascular disease was the most frequent cause of death in studies with follow-up times over 15 years. SLE progressed to ESRD in 5-11% of all SLE patients. There are no data supporting increased cancer incidence from population-based inception cohorts.
CONCLUSION
CONCLUSIONS
There is a need for more population-based studies on outcomes of SLE, especially inception studies, with the use of control groups and follow-up times over 15 years.
Identifiants
pubmed: 34640322
pii: jcm10194306
doi: 10.3390/jcm10194306
pmc: PMC8509465
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : The Dam Foundation
ID : 296618
Organisme : The Norwegian Women's Public Health Association
ID : 40108
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