Association between Serum Osteoprotegerin Levels and Severity of Coronary Artery Disease in Patients with Acute Myocardial Infarction.
SYNTAX score
coronary artery disease
myocardial infarction
osteoprotegerin
vascular calcification
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
23 Sep 2021
23 Sep 2021
Historique:
received:
16
08
2021
revised:
13
09
2021
accepted:
17
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
14
10
2021
Statut:
epublish
Résumé
Osteoprotegerin (OPG), a glycoprotein of the tumour necrosis factor (TNF) superfamily, is one of the main biomarkers for vascular calcification. We aimed to evaluate the association between serum OPG levels and extent of coronary lesions in patients with acute myocardial infarction (MI). Consecutive patients hospitalized for an acute MI who underwent coronary angiography were included. SYNTAX score was calculated to assess the severity of coronary artery disease. The population was analysed in low (5 (3-6)), medium (11 (9-13)) and high (20 (18-23)) tertiles of SYNTAX score. Among the 378 patients included, there was a gradual increase in age, rate of diabetes, anterior wall location, and a reduction in left ventricular ejection fraction across the SYNTAX tertiles. OPG levels significantly increased across the tertiles (962 (782-1497), 1240 (870-1707), and 1464 (1011-2129) pg/mL, respectively ( We found an association between OPG levels and coronary lesions complexity patients with acute MI.
Sections du résumé
BACKGROUND
BACKGROUND
Osteoprotegerin (OPG), a glycoprotein of the tumour necrosis factor (TNF) superfamily, is one of the main biomarkers for vascular calcification.
AIM
OBJECTIVE
We aimed to evaluate the association between serum OPG levels and extent of coronary lesions in patients with acute myocardial infarction (MI).
METHODS
METHODS
Consecutive patients hospitalized for an acute MI who underwent coronary angiography were included. SYNTAX score was calculated to assess the severity of coronary artery disease. The population was analysed in low (5 (3-6)), medium (11 (9-13)) and high (20 (18-23)) tertiles of SYNTAX score.
RESULTS
RESULTS
Among the 378 patients included, there was a gradual increase in age, rate of diabetes, anterior wall location, and a reduction in left ventricular ejection fraction across the SYNTAX tertiles. OPG levels significantly increased across the tertiles (962 (782-1497), 1240 (870-1707), and 1464 (1011-2129) pg/mL, respectively (
CONCLUSION
CONCLUSIONS
We found an association between OPG levels and coronary lesions complexity patients with acute MI.
Identifiants
pubmed: 34640343
pii: jcm10194326
doi: 10.3390/jcm10194326
pmc: PMC8509596
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : CHU Dijon Bourgogne
ID : NA
Organisme : Association de Cardiologie de Bourgogne
ID : NA
Organisme : Agence Régionale de Santé Bourgogne Franche Comté
ID : NA
Organisme : Conseil Régional Bourgogne Franche Comté
ID : NA
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