Complete Purging of Ewing Sarcoma Metastases from Human Ovarian Cortex Tissue Fragments by Inhibiting the mTORC1 Signaling Pathway.
Everolimus
Ewing’s sarcoma
oncofertility
ovarian tissue cryopreservation
ovarian tissue transplantation
purging
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
24 Sep 2021
24 Sep 2021
Historique:
received:
26
08
2021
revised:
20
09
2021
accepted:
23
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
14
10
2021
Statut:
epublish
Résumé
Restoration of fertility by autologous transplantation of ovarian cortex tissue in former cancer patients may lead to the reintroduction of malignancy via the graft. Pharmacological ex vivo purging of ovarian cortex fragments prior to autotransplantation may reduce the risk of reseeding the cancer. In this study we have investigated the capacity of Everolimus (EVE), an inhibitor of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, to eradicate Ewing's sarcoma (ES) from ovarian tissue by a short-term ex vivo treatment. Exposure of experimentally induced ES tumor foci in ovarian tissue to EVE for 24 h completely eliminated the malignant cells without detrimental effects on follicle morphology, survival or early folliculogenesis. This indicates that effective purging of ovarian cortex tissue from contaminating ES tumor foci is possible by short-term exposure to EVE.
Identifiants
pubmed: 34640378
pii: jcm10194362
doi: 10.3390/jcm10194362
pmc: PMC8509560
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Merck KGaA
ID : Number: A19-1294
Organisme : Radboud Oncologie Fonds
ID : KUN 00007682
Références
Reprod Fertil Dev. 2017 Sep;29(10):1982-1994
pubmed: 28143632
Hum Reprod. 2017 Jul 1;32(7):1457-1464
pubmed: 28505246
Hum Reprod. 2008 May;23(5):1151-8
pubmed: 18326514
J Clin Oncol. 2000 Sep;18(17):3108-14
pubmed: 10963639
Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3186-3191
pubmed: 28270607
Hum Reprod. 2019 Aug 1;34(8):1485-1493
pubmed: 31339993
Cancers (Basel). 2020 Jul 02;12(7):
pubmed: 32630797
Sci Rep. 2015 Nov 27;5:17323
pubmed: 26612176
J Reprod Fertil. 1986 Nov;78(2):389-401
pubmed: 3806503
Clin Cancer Res. 2010 Aug 15;16(16):4077-83
pubmed: 20547696
Hum Reprod. 2018 Jul 1;33(7):1201-1204
pubmed: 29718400
Cancer. 2000 Mar 1;88(5):1099-107
pubmed: 10699901
Hum Reprod. 2019 Mar 1;34(3):506-518
pubmed: 30597012
Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17474-9
pubmed: 24082083
Biol Reprod. 2020 Mar 13;102(3):717-729
pubmed: 31786608
Front Mol Biosci. 2020 Jan 31;6:160
pubmed: 32118030
Hum Reprod. 2019 Aug 1;34(8):1523-1535
pubmed: 31286144
Hum Reprod. 2018 Sep 1;33(9):1705-1714
pubmed: 30032281
Hum Reprod. 2015 Apr;30(4):870-6
pubmed: 25662807
Hum Reprod. 1996 Aug;11(8):1668-73
pubmed: 8921114
Tumour Biol. 2012 Oct;33(5):1349-62
pubmed: 22492237
Biochem Biophys Res Commun. 2019 Jun 11;513(4):912-918
pubmed: 31005257
Mol Hum Reprod. 2019 Nov 30;25(11):706-716
pubmed: 31588500
Cancer Res. 2009 Oct 1;69(19):7662-71
pubmed: 19789339
J Pediatr Hematol Oncol. 2018 Apr;40(3):e167-e170
pubmed: 28816797
Minerva Ginecol. 2018 Aug;70(4):444-455
pubmed: 29644331
Int J Gynecol Pathol. 2019 Sep;38(5):470-473
pubmed: 30085939
Int J Gynecol Cancer. 2007 Jan-Feb;17(1):266-9
pubmed: 17291265
Hum Reprod. 2018 Dec 1;33(12):2276-2284
pubmed: 30358835
PLoS One. 2013 Dec 02;8(12):e80060
pubmed: 24312454
J Assist Reprod Genet. 2021 Jun;38(6):1571-1588
pubmed: 33725274
Biomed Res Int. 2013;2013:861460
pubmed: 23555100
Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5326-E5333
pubmed: 29784807
Nat Commun. 2017 Jun 12;8:15680
pubmed: 28604658
J Assist Reprod Genet. 2016 Dec;33(12):1605-1614
pubmed: 27714478
Breast Cancer Res Treat. 2013 Aug;140(3):453-62
pubmed: 23907751
Front Cell Dev Biol. 2019 May 08;7:78
pubmed: 31139627
Int J Cancer. 2013 Jul 15;133(2):427-36
pubmed: 23335077
Pharmacotherapy. 2010 Oct;30(10):1044-56
pubmed: 20874042
Fetal Pediatr Pathol. 2012 Jun;31(3):159-63
pubmed: 22413993
Reprod Biomed Online. 2017 Jun;34(6):557-566
pubmed: 28372892
Hum Reprod. 2018 Mar 1;33(3):464-473
pubmed: 29304224
Oncogene. 2017 Apr 20;36(16):2191-2201
pubmed: 27748764
Am J Surg Pathol. 1998 Nov;22(11):1417-22
pubmed: 9808135
Invest New Drugs. 2013 Dec;31(6):1602-8
pubmed: 24037083
Int J Cancer. 2021 Jan 18;:
pubmed: 33460449
Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1307-16
pubmed: 25737553
Hematol Oncol Clin North Am. 2005 Jun;19(3):501-25, vi-vii
pubmed: 15939194
Reproduction. 2018 Jul;156(1):F11-F27
pubmed: 29581237
Int J Gynecol Pathol. 1993 Jan;12(1):8-19
pubmed: 8418081
Fertil Steril. 2010 Nov;94(6):2186-90
pubmed: 20100619
Hum Reprod. 2010 Jul;25(7):1708-12
pubmed: 20472912
Eur J Cancer. 2013 May;49(8):1932-8
pubmed: 23452988
Mol Hum Reprod. 2014 Aug;20(8):736-44
pubmed: 24830779
Theriogenology. 2020 Jul 1;150:8-14
pubmed: 31973967
Blood. 2012 Nov 22;120(22):4311-6
pubmed: 22709693
Cells. 2020 Mar 26;9(4):
pubmed: 32225029
Int J Gynecol Pathol. 1990;9(3):231-52
pubmed: 2373588
Exp Anim. 2018 Nov 1;67(4):493-500
pubmed: 29937473
Mol Biol Rep. 2020 Nov;47(11):8711-8726
pubmed: 33079326
Blood. 2009 Apr 2;113(14):3297-306
pubmed: 19196656
Fertil Steril. 2021 May;115(5):1102-1115
pubmed: 33933173
Mol Hum Reprod. 2018 Mar 1;24(3):135-142
pubmed: 29390119
Endocr Rev. 2020 Dec 1;41(6):
pubmed: 32761180