NLRC4 GOF Mutations, a Challenging Diagnosis from Neonatal Age to Adulthood.

NLRC4 allergy autoinflammatory diseases inflammasome inflammasomopathy sepsis

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
24 Sep 2021
Historique:
received: 06 07 2021
revised: 29 08 2021
accepted: 13 09 2021
entrez: 13 10 2021
pubmed: 14 10 2021
medline: 14 10 2021
Statut: epublish

Résumé

The NLRC4 inflammasome is part of the human immune innate system. Its activation leads to the cleavage of pro-inflammatory cytokines IL-1β and IL-18, promoting inflammation.

Identifiants

pubmed: 34640385
pii: jcm10194369
doi: 10.3390/jcm10194369
pmc: PMC8509521
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Juliette Bardet (J)

Pediatric Nephrology, Rheumatology, Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 69677 Bron, France.
Pediatric Hepatology, Gastroenterology and Nutrition Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 69677 Bron, France.

Noémie Laverdure (N)

Pediatric Hepatology, Gastroenterology and Nutrition Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 69677 Bron, France.

Mathieu Fusaro (M)

Study Center for Primary Immunodeficiencies, AP-HP, Necker Hospital for Sick Children, Université Paris, 75015 Paris, France.

Capucine Picard (C)

Study Center for Primary Immunodeficiencies, AP-HP, Necker Hospital for Sick Children, Université Paris, 75015 Paris, France.

Lorna Garnier (L)

Immunology Department, Lyon Sud University Hospital, 69495 Pierre-Bénite, France.

Sébastien Viel (S)

Immunology Department, Lyon Sud University Hospital, 69495 Pierre-Bénite, France.
International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, 69007 Lyon, France.
National Referee Centre for Rheumatic and AutoImmune and Systemic Diseases in Children (RAISE), 69677 Bron, France.
Lyon Immunopathology Federation LIFE, Hospices Civils de Lyon, 69002 Lyon, France.

Sophie Collardeau-Frachon (S)

Department of Pathology, Hospices Civils de Lyon-Hôpital Femme-Mère-Enfant, Claude Bernard Lyon 1 University, 69677 Bron, France.

Jean-Marie De Guillebon (JM)

Pediatric Nephrology, Rheumatology, Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 69677 Bron, France.

Isabelle Durieu (I)

Adult Cystic Fibrosis Center, Internal Medicine and Vascular Pathology Department, Groupement Hospitalier Lyon-Sud, Hospices Civils de Lyon, 69310 Pierre-Bénite, France.
Department of Internal and Vascular Medicine, Hôpital Lyon Sud, Hospices Civils de Lyon, 69310 Pierre-Bénite, France.
Faculty of Medicine, University of Lyon, 69100 Villeurbanne, France.

Clémence Casari-Thery (C)

National Referee Centre for Rheumatic and AutoImmune and Systemic Diseases in Children (RAISE), 69677 Bron, France.
Department of Internal and Vascular Medicine, Hôpital Lyon Sud, Hospices Civils de Lyon, 69310 Pierre-Bénite, France.
Faculty of Medicine, University of Lyon, 69100 Villeurbanne, France.

Guillaume Mortamet (G)

Pediatric Intensive Care Unit, Grenoble Alpes University Hospital, 38700 La Tronche, France.

Audrey Laurent (A)

Pediatric Nephrology, Rheumatology, Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 69677 Bron, France.
National Referee Centre for Rheumatic and AutoImmune and Systemic Diseases in Children (RAISE), 69677 Bron, France.

Alexandre Belot (A)

Pediatric Nephrology, Rheumatology, Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 69677 Bron, France.
International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, 69007 Lyon, France.
National Referee Centre for Rheumatic and AutoImmune and Systemic Diseases in Children (RAISE), 69677 Bron, France.
Lyon Immunopathology Federation LIFE, Hospices Civils de Lyon, 69002 Lyon, France.
Faculty of Medicine, University of Lyon, 69100 Villeurbanne, France.

Classifications MeSH