Towards a Consensus on Alzheimer's Disease Comorbidity?
Alzheimer’s disease
bioinformatics
comorbidity
oxidative stress
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
24 Sep 2021
24 Sep 2021
Historique:
received:
15
07
2021
revised:
08
09
2021
accepted:
14
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
14
10
2021
Statut:
epublish
Résumé
Alzheimer's disease (AD) is often comorbid with other pathologies. First, we review shortly the diseases most associated with AD in the clinic. Then we query PubMed citations for the co-occurrence of AD with other diseases, using a list of 400 common pathologies. Significantly, AD is found to be associated with schizophrenia and psychosis, sleep insomnia and apnea, type 2 diabetes, atherosclerosis, hypertension, cardiovascular diseases, obesity, fibrillation, osteoporosis, arthritis, glaucoma, metabolic syndrome, pain, herpes, HIV, alcoholism, heart failure, migraine, pneumonia, dyslipidemia, COPD and asthma, hearing loss, and tobacco smoking. Trivially, AD is also found to be associated with several neurodegenerative diseases, which are disregarded. Notably, our predicted results are consistent with the previously published clinical data and correlate nicely with individual publications. Our results emphasize risk factors and promulgate diseases often associated with AD. Interestingly, the comorbid diseases are often degenerative diseases exacerbated by reactive oxygen species, thus underlining the potential role of antioxidants in the treatment of AD and comorbid diseases.
Identifiants
pubmed: 34640387
pii: jcm10194360
doi: 10.3390/jcm10194360
pmc: PMC8509357
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Dement Geriatr Cogn Dis Extra. 2019 Jul 11;9(2):250-259
pubmed: 31543892
Diabetes. 2017 Jun;66(6):1636-1649
pubmed: 28356309
Curr Alzheimer Res. 2017;14(4):426-440
pubmed: 27697063
J Alzheimers Dis Rep. 2020 Jun 16;4(1):175-183
pubmed: 32715278
Hypertens Res. 2011 Jun;34(6):665-73
pubmed: 21512515
Curr Neuropharmacol. 2018;16(7):971-977
pubmed: 29210654
J Neuroinflammation. 2019 Nov 6;16(1):204
pubmed: 31694670
Z Gerontol Geriatr. 2015 Jun;48(4):305-11
pubmed: 25962363
JAMA Psychiatry. 2015 Nov;72(11):1095-101
pubmed: 26444987
Methods. 2015 Mar;74:83-9
pubmed: 25484339
Am J Med. 2018 Oct;131(10):1161-1169
pubmed: 29425707
Ci Ji Yi Xue Za Zhi. 2017 Jul-Sep;29(3):138-142
pubmed: 28974906
BMC Bioinformatics. 2018 Feb 07;19(1):37
pubmed: 29415654
J Biochem Mol Toxicol. 2003;17(1):24-38
pubmed: 12616644
Can J Cardiol. 2006 Feb;22 Suppl B:61B-65B
pubmed: 16498514
J Intern Med. 2015 Oct;278(4):369-95
pubmed: 26212387
Alzheimers Dement (Amst). 2017 Nov 01;9:67-75
pubmed: 29201992
Cureus. 2020 May 19;12(5):e8203
pubmed: 32572359
J Intern Med. 2006 Sep;260(3):211-23
pubmed: 16918818
BMJ. 2009 Feb 05;338:b158
pubmed: 19196745
Autoimmun Rev. 2021 Apr;20(4):102776
pubmed: 33609792
Oxid Med Cell Longev. 2018 Jul 31;2018:2673076
pubmed: 30151068
Nat Commun. 2021 Apr 20;12(1):2289
pubmed: 33879784
Nature. 2018 Jul;559(7715):S2-S3
pubmed: 30046085
J Glob Antimicrob Resist. 2016 Dec;7:132-134
pubmed: 27788414
Life Sci. 2009 May 22;84(21-22):705-12
pubmed: 19281826
J Alzheimers Dis. 2010;21(4):1077-87
pubmed: 21504132
BMJ Open. 2017 Mar 9;7(3):e012546
pubmed: 28279992
Front Cell Neurosci. 2018 Sep 11;12:307
pubmed: 30254568
Neural Regen Res. 2021 Mar;16(3):496-497
pubmed: 32985471
J Alzheimers Dis. 2018;63(2):773-781
pubmed: 29660933
Postgrad Med J. 1992 Aug;68(802):673-6
pubmed: 1448411
J Alzheimers Dis. 2012;31(3):669-76
pubmed: 22647255
J Alzheimers Dis. 2020;73(2):443-454
pubmed: 31839609
N Engl J Med. 2010 Jan 28;362(4):329-44
pubmed: 20107219
Open Biol. 2020 Jun;10(6):200084
pubmed: 32543351
Mol Neurodegener. 2019 Jun 11;14(1):23
pubmed: 31186026
Neurologist. 2009 Mar;15(2):55-8
pubmed: 19276782
Mech Ageing Dev. 2009 Jan-Feb;130(1-2):98-104
pubmed: 18452970
J Nutr. 2012 Sep;142(9):1693-704
pubmed: 22810988
Neural Regen Res. 2021 Feb;16(2):310-311
pubmed: 32859789
Transl Neurosci. 2018 May 31;9:43-53
pubmed: 29876138
Lancet. 2011 Mar 19;377(9770):1019-31
pubmed: 21371747
Mol Psychiatry. 2021 Jan;26(1):280-295
pubmed: 32382138
Nucleic Acids Res. 2015 Jul 1;43(W1):W566-70
pubmed: 25969447
Arch Neurol. 2007 Jan;64(1):93-6
pubmed: 17210814
Database (Oxford). 2016 Nov 25;2016:
pubmed: 27888231
F1000Res. 2020 Nov 5;9:1299
pubmed: 33633844
J Alzheimers Dis. 2019;71(1):307-316
pubmed: 31381518
J Headache Pain. 2020 Aug 6;21(1):98
pubmed: 32762715
Essays Biochem. 2007;43:153-64
pubmed: 17705799
Mol Syst Biol. 2010;6:343
pubmed: 20087340
J Epidemiol. 2015;25(8):517-21
pubmed: 25986155
Int J Environ Res Public Health. 2020 May 13;17(10):
pubmed: 32414124
Arch Neurol. 1989 Feb;46(2):157-61
pubmed: 2916954
Curr Alzheimer Res. 2016;13(12):1356-1362
pubmed: 27628432
Compr Psychiatry. 1996 May-Jun;37(3):188-95
pubmed: 8732586
PLoS Pathog. 2020 Jun 18;16(6):e1008575
pubmed: 32555685
Oxid Med Cell Longev. 2016;2016:7124251
pubmed: 27516832
Aging (Albany NY). 2021 Apr 3;13(7):10770-10795
pubmed: 33811757