Delirium in Critically Ill Patients with and without COVID-19-A Retrospective Analysis.
COVID-19
Nudesc
SARS-CoV-2
delirium
intensive care unit
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
26 Sep 2021
26 Sep 2021
Historique:
received:
23
08
2021
revised:
22
09
2021
accepted:
24
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
14
10
2021
Statut:
epublish
Résumé
Delirium complicating the course of Intensive care unit (ICU) therapy is a known driver of morbidity and mortality. It has been speculated that infection with the neurotrophic SARS-CoV-2 might promote delirium. Retrospective registry analysis including all patients treated at least 48 h on a medical intensive care unit. The primary endpoint was development of delirium as diagnosed by Nursing Delirium screening scale ≥2. Results were confirmed by propensity score matching. 542 patients were included. The primary endpoint was reached in 352/542 (64.9%) patients, without significant differences between COVID-19 patients and non-COVID-19 patients (51.4% and 65.9%, respectively, Delirium is frequent in critically ill patients with and without COVID-19 treated at an intensive care unit. Data suggests that COVID-19 itself is not a driver of delirium per se.
Sections du résumé
BACKGROUND
BACKGROUND
Delirium complicating the course of Intensive care unit (ICU) therapy is a known driver of morbidity and mortality. It has been speculated that infection with the neurotrophic SARS-CoV-2 might promote delirium.
METHODS
METHODS
Retrospective registry analysis including all patients treated at least 48 h on a medical intensive care unit. The primary endpoint was development of delirium as diagnosed by Nursing Delirium screening scale ≥2. Results were confirmed by propensity score matching.
RESULTS
RESULTS
542 patients were included. The primary endpoint was reached in 352/542 (64.9%) patients, without significant differences between COVID-19 patients and non-COVID-19 patients (51.4% and 65.9%, respectively,
CONCLUSION
CONCLUSIONS
Delirium is frequent in critically ill patients with and without COVID-19 treated at an intensive care unit. Data suggests that COVID-19 itself is not a driver of delirium per se.
Identifiants
pubmed: 34640428
pii: jcm10194412
doi: 10.3390/jcm10194412
pmc: PMC8509381
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Respir Med. 2021 Sep;186:106516
pubmed: 34218168
Catheter Cardiovasc Interv. 2020 Sep 14;:
pubmed: 32926556
Int J Nurs Stud. 2012 Jul;49(7):775-83
pubmed: 22197051
Biol Direct. 2020 Nov 27;15(1):28
pubmed: 33246479
Lancet Respir Med. 2021 Mar;9(3):239-250
pubmed: 33428871
BMC Nurs. 2020 Jul 31;19:72
pubmed: 32760215
J Am Geriatr Soc. 2006 Mar;54(3):479-84
pubmed: 16551316
Am J Respir Crit Care Med. 2002 Nov 15;166(10):1338-44
pubmed: 12421743
Lancet Respir Med. 2020 May;8(5):475-481
pubmed: 32105632
Crit Care. 2005 Aug;9(4):R375-81
pubmed: 16137350
J Am Geriatr Soc. 2012 Apr;60(4):669-75
pubmed: 22316182
Am J Respir Crit Care Med. 2015 Jan 1;191(1):71-8
pubmed: 25393331
Crit Care Med. 2010 Feb;38(2):409-18
pubmed: 20029345
Intensive Care Med. 2021 Oct;47(10):1144-1147
pubmed: 34191039
JAMA. 2020 May 26;323(20):2052-2059
pubmed: 32320003
Lancet. 2007 Oct 20;370(9596):1453-7
pubmed: 18064739
J Exp Med. 2021 Mar 1;218(3):
pubmed: 33433624
JAMA. 2004 Apr 14;291(14):1753-62
pubmed: 15082703
N Engl J Med. 2020 Jun 11;382(24):2372-2374
pubmed: 32302078
Z Evid Fortbild Qual Gesundhwes. 2016 Oct;115-116:33-48
pubmed: 27837958
Crit Care. 2020 Aug 8;24(1):491
pubmed: 32771053
Crit Care. 2020 Apr 28;24(1):176
pubmed: 32345343
Am J Respir Crit Care Med. 2017 Jun 15;195(12):1597-1607
pubmed: 27854517
Lancet. 2020 Jun 6;395(10239):1763-1770
pubmed: 32442528
Crit Care Med. 2004 Nov;32(11):2254-9
pubmed: 15640638
Arch Intern Med. 2007 Aug 13-27;167(15):1629-34
pubmed: 17698685
Int J Geriatr Psychiatry. 2018 Nov;33(11):1428-1457
pubmed: 29278283
J Nurs Scholarsh. 2007;39(2):147-54
pubmed: 17535315
J Pain Symptom Manage. 2005 Apr;29(4):368-75
pubmed: 15857740
Crit Care. 2020 Jul 9;24(1):401
pubmed: 32646464
Rev Bras Anestesiol. 2012 Jul;62(4):469-83
pubmed: 22793963
J Am Coll Surg. 2012 Jul;215(1):12-7; discussion 17-8
pubmed: 22626912