Overexpression of the Gene Encoding Neurosecretory Protein GL Precursor Prevents Excessive Fat Accumulation in the Adipose Tissue of Mice Fed a Long-Term High-Fat Diet.
Adipose Tissue
/ metabolism
Adipose Tissue, White
/ metabolism
Animals
Biomarkers
/ blood
Body Weight
Diet, High-Fat
Energy Metabolism
/ genetics
Feeding Behavior
Glucose Tolerance Test
Insulin
/ blood
Lipid Metabolism
/ genetics
Male
Mice
Mice, Inbred C57BL
Nerve Tissue Proteins
/ genetics
Obesity
/ blood
RNA, Messenger
/ metabolism
glucose tolerance
hypothalamus
insulin sensitivity
neuropeptide
neurosecretory protein GL
obesity
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
03 Oct 2021
03 Oct 2021
Historique:
received:
31
08
2021
revised:
29
09
2021
accepted:
30
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
18
11
2021
Statut:
epublish
Résumé
We previously identified a novel small hypothalamic protein, neurosecretory protein GL (NPGL), which induces feeding behavior and fat accumulation in rodents depending on their diet. In the present study, we explored the effects of NPGL on feeding behavior and energy metabolism in mice placed on a long-term high-fat diet with 60% calories from fat (HFD 60). Overexpression of the NPGL precursor gene (
Identifiants
pubmed: 34641550
pii: molecules26196006
doi: 10.3390/molecules26196006
pmc: PMC8512635
pii:
doi:
Substances chimiques
Biomarkers
0
Insulin
0
Nerve Tissue Proteins
0
RNA, Messenger
0
neurosecretory protein GL, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : JP20K22741
Organisme : Japan Society for the Promotion of Science
ID : JP19K06768
Organisme : Japan Society for the Promotion of Science
ID : JP19H03258
Organisme : the Takeda Science Foundation
ID : none
Organisme : the Uehara Memorial Foundation
ID : none
Organisme : the Ono Medical Research Foundation
ID : none
Références
Elife. 2017 Aug 11;6:
pubmed: 28799896
Front Neuroendocrinol. 2010 Jan;31(1):44-60
pubmed: 19896496
Neuron. 2003 Feb 20;37(4):649-61
pubmed: 12597862
Nat Rev Genet. 2017 Dec;18(12):731-748
pubmed: 28989171
Am J Physiol. 1995 Mar;268(3 Pt 2):R744-51
pubmed: 7900918
Mol Cell Endocrinol. 2010 Apr 29;318(1-2):34-43
pubmed: 19747957
Lancet. 2005 Oct 1;366(9492):1197-209
pubmed: 16198769
Nat Rev Neurosci. 2014 Jun;15(6):367-78
pubmed: 24840801
Neuron. 2017 Aug 16;95(4):757-778
pubmed: 28817798
Int J Obes (Lond). 2018 Jun;42(5):1088-1091
pubmed: 29463918
Am J Physiol Regul Integr Comp Physiol. 2004 Jun;286(6):R1167-75
pubmed: 15142857
Nature. 1994 Dec 1;372(6505):425-32
pubmed: 7984236
Biochem Biophys Res Commun. 2014 Mar 28;446(1):298-303
pubmed: 24582750
Nature. 2006 Sep 21;443(7109):289-95
pubmed: 16988703
J Lipid Res. 2014 Dec;55(12):2541-53
pubmed: 25271296
Front Endocrinol (Lausanne). 2019 Jun 19;10:392
pubmed: 31275247
Front Neurosci. 2013 Apr 08;7:51
pubmed: 23579596
J Clin Invest. 2005 Oct;115(10):2843-54
pubmed: 16184193
Diabetes. 2001 Nov;50(11):2438-43
pubmed: 11679419
Physiol Behav. 2007 Jul 24;91(4):343-51
pubmed: 17521684
NMR Biomed. 2009 Apr;22(3):310-7
pubmed: 19012281
Biosci Biotechnol Biochem. 2021 May 25;85(6):1514-1520
pubmed: 33851987
Nat Med. 2005 Feb;11(2):183-90
pubmed: 15685173
Curr Opin Pharmacol. 2017 Dec;37:35-40
pubmed: 28843953
Physiol Rev. 2018 Oct 1;98(4):2133-2223
pubmed: 30067154
Annu Rev Immunol. 2011;29:415-45
pubmed: 21219177
Science. 2005 Jan 21;307(5708):375-9
pubmed: 15662002
J Neurosci. 2014 Apr 16;34(16):5486-96
pubmed: 24741039
Eur Cytokine Netw. 2006 Mar;17(1):4-12
pubmed: 16613757
Gen Comp Endocrinol. 2018 Jan 15;256:37-42
pubmed: 28554734
Neuron. 2011 Jul 14;71(1):142-54
pubmed: 21745644
J Endocrinol. 2020 Jan 1;244(1):1-12
pubmed: 31536964
Physiol Behav. 2020 Oct 1;224:113039
pubmed: 32610101
Nature. 1983 Apr 21;302(5910):716-8
pubmed: 6835407
Endocrinology. 2015 Oct;156(10):3680-94
pubmed: 26132918
Cell Metab. 2017 Aug 1;26(2):324-341
pubmed: 28768172
Annu Rev Physiol. 2010;72:219-46
pubmed: 20148674
Cell Metab. 2016 Aug 9;24(2):295-310
pubmed: 27508875
Am J Physiol. 1998 Jul;275(1):R291-9
pubmed: 9688991
Ann N Y Acad Sci. 2017 Mar;1391(1):35-53
pubmed: 27768821
J Vis Exp. 2018 Jan 7;(131):
pubmed: 29364280
Gen Comp Endocrinol. 2018 May 1;260:164-170
pubmed: 28951261
Diabetes. 2012 Dec;61(12):3228-38
pubmed: 23011592
Int J Mol Sci. 2021 Apr 28;22(9):
pubmed: 33925193
Endocrinology. 2017 May 1;158(5):1120-1129
pubmed: 28323972
Diabetologia. 1985 Sep;28(9):704-7
pubmed: 3905480
J Diabetes Investig. 2010 Apr 22;1(1-2):8-23
pubmed: 24843404
Nature. 2001 May 24;411(6836):480-4
pubmed: 11373681
Annu Rev Psychol. 2008;59:55-92
pubmed: 18154499
Nature. 2001 Jan 11;409(6817):194-8
pubmed: 11196643
J Clin Invest. 2008 Jun;118(6):2132-47
pubmed: 18451994
Pharmacoeconomics. 2015 Jul;33(7):673-89
pubmed: 25471927
Neuroendocrinology. 2021 Aug 12;:
pubmed: 34384081