Therapeutic plasma exchange in patients with COVID-19 pneumonia in intensive care unit: Cases series.
Acute respiratory distress syndrome
COVID 19 pneumonia
Cytokine strom
Therapeutic plasma exchange
Journal
Annals of medicine and surgery (2012)
ISSN: 2049-0801
Titre abrégé: Ann Med Surg (Lond)
Pays: England
ID NLM: 101616869
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
18
08
2021
revised:
03
10
2021
accepted:
03
10
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
14
10
2021
Statut:
ppublish
Résumé
COVID 19 pneumonia can lead to an inappropriate inflammatory response, and can be complicated by acute respiratory distress syndrome, multivisceral failure with a high mortality rate. To observe the effect of therapeutic plasma exchange on the excessive inflammatory response. In this study, we included 7 confirmed cases of COVID-19 in the intensive care unit (ICU) department of the university hospital of Oujda. COVID-19 cases were confirmed by RT PCR (reverse transcription-polymerase chain) and CT (computerized tomography) imaging according to WHO guidelines. Therapeutic plasma exchange was performed decrease cytokine storm-induced ARDS (Acute respiratory distress syndrome). Inflammation marker assays were performed before and after therapeutic plasma exchange to assess its efficacy. Levels of inflammatory cytokines (IL-6) and acute phase response proteins, including ferritin and CRP, were elevated before therapeutic plasma exchange.After therapeutic plasma exchange, levels of acute phase reactants, inflammatory mediators, were significantly reduced (p < 0.05). Our data suggest that therapeutic plasma exchange reduces the inflammatory response in patients with severe COVID-19 not undergoing mechanical ventilation. Further studies are needed to explore the efficacy of therapeutic plasma exchange in patients with COVID-19.
Identifiants
pubmed: 34642602
doi: 10.1016/j.amsu.2021.102920
pii: S2049-0801(21)00870-0
pmc: PMC8495054
doi:
Types de publication
Journal Article
Langues
eng
Pagination
102920Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors state that they have no conflicts of interest for this case series.
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