A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program.

Journal

medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986

Informations de publication

Date de publication:
15 Oct 2021
Historique:
pubmed: 14 10 2021
medline: 14 10 2021
entrez: 13 10 2021
Statut: epublish

Résumé

The study aims to determine the shared genetic architecture between COVID-19 severity with existing medical conditions using electronic health record (EHR) data. We conducted a Phenome-Wide Association Study (PheWAS) of genetic variants associated with critical illness (n=35) or hospitalization (n=42) due to severe COVID-19 using genome-wide association summary from the Host Genetics Initiative. PheWAS analysis was performed using genotype-phenotype data from the Veterans Affairs Million Veteran Program (MVP). Phenotypes were defined by International Classification of Diseases (ICD) codes mapped to clinically relevant groups using published PheWAS methods. Among 658,582 Veterans, variants associated with severe COVID-19 were tested for association across 1,559 phenotypes. Variants at the

Identifiants

DOI: 10.1101/2021.05.18.21257396 PMID: 34642702 PMC: PMC8509103
pubmed: 34642702
doi: 10.1101/2021.05.18.21257396
pmc: PMC8509103
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : CSRD VA
ID : I01 CX001727
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_20058
Pays : United Kingdom
Organisme : NIAMS NIH HHS
ID : P30 AR072577
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA026302
Pays : United States

Commentaires et corrections

Type : UpdateIn

Auteurs

Anurag Verma (A)

Corporal Michael Crescenz VA Medical Center, Philadelphia, Philadelphia, USA.
Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Noah Tsao (N)

Corporal Michael Crescenz VA Medical Center, Philadelphia, Philadelphia, USA.
Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Lauren Thomann (L)

VA Boston Healthcare System, Boston, Massachusetts, USA.

Yuk-Lam Ho (YL)

Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, USA.

Sudha Iyengar (S)

Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.

Shiuh-Wen Luoh (SW)

VA Portland Health Care System, Portland OR, USA.
Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA.

Rotonya Carr (R)

Corporal Michael Crescenz VA Medical Center, Philadelphia, Philadelphia, USA.
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
University of Washington, Division of Gastroenterology Seattle, WA USA.

Dana Crawford (D)

Cleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA.

Jimmy T Efird (JT)

Cardiovascular Medicine Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Jennifer Huffman (J)

VA Boston Healthcare System, Boston, Massachusetts, USA.

Adriana Hung (A)

Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA.
Cooperative Studies Program Epidemiology Center, Health Services Research and Development, DVAHCS (Duke University Affiliate), Durham, North Carolina, USA.

Kerry Ivey (K)

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Tennessee Valley Healthcare System (Nashville VA) & Vanderbilt University, Nashville, Tennessee, USA.
Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.

Michael Levin (M)

VA Portland Health Care System, Portland OR, USA.
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA.

Julie Lynch (J)

VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, Utah, USA.

Pradeep Natarajan (P)

VA Boston Healthcare System, Boston, Massachusetts, USA.
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard & MIT, Cambridge, Massachusetts, USA.

Saiju Pyarajan (S)

VA Boston Healthcare System, Boston, Massachusetts, USA.
Harvard Medical School, Boston, Massachusetts, USA.

Alexander Bick (A)

VA Boston Healthcare System, Boston, Massachusetts, USA.
Vanderbilt University, Nashville, Tennessee, USA.

Lauren Costa (L)

Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, USA.

Giulio Genovese (G)

Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard & MIT, Cambridge, Massachusetts, USA.
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Genetics, Harvard Medical School, Boston, MA, USA.

Richard Hauger (R)

Department of Psychiatry, University of California, San Diego, La Jolla, CA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, USA.

Ravi Madduri (R)

University of Chicago Consortium for Advanced Science and Engineering, The University of Chicago, Chicago, Illinois, USA.
Data Science and Learning Division, Argonne National Laboratory, Lemont, Illinois.

Gita Pathak (G)

VA Connecticut Healthcare System, West Haven, CT, USA.
Department of Psychiatry, Yale School of Medicine, Connecticut, USA.

Renato Polimanti (R)

VA Connecticut Healthcare System, West Haven, CT, USA.
Department of Psychiatry, Yale School of Medicine, Connecticut, USA.

Benjamin Voight (B)

Corporal Michael Crescenz VA Medical Center, Philadelphia, Philadelphia, USA.
Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Marijana Vujkovic (M)

Corporal Michael Crescenz VA Medical Center, Philadelphia, Philadelphia, USA.
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Maryam Zekavat (M)

VA Boston Healthcare System, Boston, Massachusetts, USA.
Broad Institute of MIT & Harvard, Cambridge, MA, USA.
Yale School of Medicine New Haven, CT, USA.

Hongyu Zhao (H)

VA Connecticut Healthcare System, West Haven, CT, USA.
Yale School of Medicine New Haven, CT, USA.
Computational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA.

Marylyn D Ritchie (MD)

VA Portland Health Care System, Portland OR, USA.

Kyong-Mi Chang (KM)

Corporal Michael Crescenz VA Medical Center, Philadelphia, Philadelphia, USA.
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Kelly Cho (K)

Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, USA.

Juan P Casas (JP)

Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, USA.
Brigham and Women's Hospital, Boston, Massachusetts, USA.

Philip S Tsao (PS)

VA Palo Alto Health Care System, Palo Alto, California, USA.
Department of Medicine (Cardiovascular Medicine), Stanford University School of Medicine, Stanford, CA, USA.

J Michael Gaziano (JM)

Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, USA.
Brigham and Women's Hospital, Boston, Massachusetts, USA.

Christopher O'Donnell (C)

VA Boston Healthcare System, Boston, Massachusetts, USA.
Harvard Medical School, Boston, Massachusetts, USA.
Brigham and Women's Hospital, Boston, Massachusetts, USA.

Scott Damrauer (S)

Corporal Michael Crescenz VA Medical Center, Philadelphia, Philadelphia, USA.
Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Katherine Liao (K)

VA Boston Healthcare System, Boston, Massachusetts, USA.
Harvard Medical School, Boston, Massachusetts, USA.
Brigham and Women's Hospital, Boston, Massachusetts, USA.

Classifications MeSH