Synthesis and pharmacological characterisation of arctigenin analogues as antagonists of AMPA and kainate receptors.

Receptors, Kainic Acid

Journal

Organic & biomolecular chemistry
ISSN: 1477-0539
Titre abrégé: Org Biomol Chem
Pays: England
ID NLM: 101154995

Informations de publication

Date de publication:
03 11 2021
Historique:
pubmed: 14 10 2021
medline: 18 3 2022
entrez: 13 10 2021
Statut: epublish

Résumé

(-)-Arctigenin and a series of new analogues have been synthesised and then tested for their potential as AMPA and kainate receptor antagonists of human homomeric GluA1 and GluK2 receptors expressed in HEK293 cells using a Ca

Identifiants

DOI: 10.1039/d1ob01653a PMID: 34642722
pubmed: 34642722
doi: 10.1039/d1ob01653a
doi:

Substances chimiques

Receptors, Kainic Acid 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9154-9162

Auteurs

Lisa-Maria Rečnik (LM)

School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK. chris.willis@bristol.ac.uk.
School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK.
ORCID: 0000-0002-3815-7981

Robert J Thatcher (RJ)

School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK.
ORCID: 0000-0002-9405-6771

Shahida Mallah (S)

School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK.

Craig P Butts (CP)

School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK. chris.willis@bristol.ac.uk.
ORCID: 0000-0001-6678-8839

Graham L Collingridge (GL)

School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK.
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON M5S 1A8, Canada.
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
ORCID: 0000-0002-9572-5359

Elek Molnár (E)

School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK.
ORCID: 0000-0002-3525-4671

David E Jane (DE)

School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK.

Christine L Willis (CL)

School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK. chris.willis@bristol.ac.uk.
ORCID: 0000-0002-3919-3642

Articles similaires

Cortical nitric oxide required for presynaptic long-term potentiation in the insular cortex.

Kiyofumi Yamamoto, Qi-Yu Chen, Zhaoxiang Zhou et al.
1.00
Long-Term Potentiation Nitric Oxide Animals Cerebral Cortex Presynaptic Terminals

A Pathogenic Missense Mutation in Kainate Receptors Elevates Dendritic Excitability and Synaptic Integration through Dysregulation of SK Channels.

Toshihiro Nomura, Sakiko Taniguchi, Yi-Zhi Wang et al.
1.00
Male Female Humans Mice Animals

Presynaptic Kainate Receptors onto Somatostatin Interneurons Are Recruited by Activity throughout Development and Contribute to Cortical Sensory Adaptation.

Tevye J Stachniak, Ali Ö Argunsah, Jenq-Wei Yang et al.
1.00
Male Female Mice Animals Kainic Acid

Role of kainate receptors in pruriceptive processing in the mouse spinal cord.

Ayaka Haruta-Tsukamoto, Anna Kanemaru-Kawazoe, Yoichiro Kogoh et al.
1.00
Animals Mice Receptors, Kainic Acid 6-Cyano-7-nitroquinoxaline-2,3-dione Histamine

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Récepteurs ionotropes du glutamate › Récepteurs kaïnate › Synthesis and pharmacological characterisation...