Modeling Brain-Heart Crosstalk Information in Patients with Traumatic Brain Injury.
CENTER-TBI
Intracranial pressure
Raised heart rate
Raised intracranial pressure
Traumatic brain injury
Journal
Neurocritical care
ISSN: 1556-0961
Titre abrégé: Neurocrit Care
Pays: United States
ID NLM: 101156086
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
13
11
2020
accepted:
09
09
2021
pubmed:
14
10
2021
medline:
20
5
2022
entrez:
13
10
2021
Statut:
ppublish
Résumé
Traumatic brain injury (TBI) is an extremely heterogeneous and complex pathology that requires the integration of different physiological measurements for the optimal understanding and clinical management of patients. Information derived from intracranial pressure (ICP) monitoring can be coupled with information obtained from heart rate (HR) monitoring to assess the interplay between brain and heart. The goal of our study is to investigate events of simultaneous increases in HR and ICP and their relationship with patient mortality.. In our previous work, we introduced a novel measure of brain-heart interaction termed brain-heart crosstalks (ct A total of 226 patients with TBI were included in this cohort. The data set included monitored parameters (ICP and HR), as well as laboratory, demographics, and clinical information. The number of detected brain-heart crosstalks varied (mean 58, standard deviation 57). The Kruskal-Wallis test comparing brain-heart crosstalks measures of survivors and nonsurvivors showed statistically significant differences between the two distributions (p values: 0.02 for [Formula: see text], 0.005 for ct The presence of a negative relationship between mortality and brain-heart crosstalks indicators suggests that a healthy brain-cardiovascular interaction plays a role in TBI.
Sections du résumé
BACKGROUND
Traumatic brain injury (TBI) is an extremely heterogeneous and complex pathology that requires the integration of different physiological measurements for the optimal understanding and clinical management of patients. Information derived from intracranial pressure (ICP) monitoring can be coupled with information obtained from heart rate (HR) monitoring to assess the interplay between brain and heart. The goal of our study is to investigate events of simultaneous increases in HR and ICP and their relationship with patient mortality..
METHODS
In our previous work, we introduced a novel measure of brain-heart interaction termed brain-heart crosstalks (ct
RESULTS
A total of 226 patients with TBI were included in this cohort. The data set included monitored parameters (ICP and HR), as well as laboratory, demographics, and clinical information. The number of detected brain-heart crosstalks varied (mean 58, standard deviation 57). The Kruskal-Wallis test comparing brain-heart crosstalks measures of survivors and nonsurvivors showed statistically significant differences between the two distributions (p values: 0.02 for [Formula: see text], 0.005 for ct
CONCLUSIONS
The presence of a negative relationship between mortality and brain-heart crosstalks indicators suggests that a healthy brain-cardiovascular interaction plays a role in TBI.
Identifiants
pubmed: 34642842
doi: 10.1007/s12028-021-01353-7
pii: 10.1007/s12028-021-01353-7
pmc: PMC9110542
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
738-750Investigateurs
Audny Anke
(A)
Ronny Beer
(R)
Bo-Michael Bellander
(BM)
Erta Beqiri
(E)
Andras Buki
(A)
Manuel Cabeleira
(M)
Marco Carbonara
(M)
Arturo Chieregato
(A)
Giuseppe Citerio
(G)
Hans Clusmann
(H)
Endre Czeiter
(E)
Marek Czosnyka
(M)
Bart Depreitere
(B)
Ari Ercole
(A)
Shirin Frisvold
(S)
Raimund Helbok
(R)
Stefan Jankowski
(S)
Daniel Kondziella
(D)
Lars-Owe Koskinen
(LO)
Ana Kowark
(A)
David K Menon
(DK)
Geert Meyfroidt
(G)
Kirsten Moeller
(K)
David Nelson
(D)
Anna Piippo-Karjalainen
(A)
Andreea Radoi
(A)
Arminas Ragauskas
(A)
Rahul Raj
(R)
Jonathan Rhodes
(J)
Saulius Rocka
(S)
Rolf Rossaint
(R)
Juan Sahuquillo
(J)
Oliver Sakowitz
(O)
Peter Smielewski
(P)
Nino Stocchetti
(N)
Nina Sundström
(N)
Riikka Takala
(R)
Tomas Tamosuitis
(T)
Olli Tenovuo
(O)
Andreas Unterberg
(A)
Peter Vajkoczy
(P)
Alessia Vargiolu
(A)
Rimantas Vilcinis
(R)
Stefan Wolf
(S)
Alexander Younsi
(A)
Frederick A Zeiler
(FA)
Informations de copyright
© 2021. The Author(s).
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