The current status of preclinical proton FLASH radiation and future directions.
FLASH radiobiology
preclinical protons
proton FLASH
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
revised:
12
09
2021
received:
06
05
2021
accepted:
17
09
2021
pubmed:
14
10
2021
medline:
11
3
2022
entrez:
13
10
2021
Statut:
ppublish
Résumé
We review the current status of proton FLASH experimental systems, including preclinical physical and biological results. Technological limitations on preclinical investigation of FLASH biological mechanisms and determination of clinically relevant parameters are discussed. A review of the biological data reveals no reproduced proton FLASH effect in vitro and a significant in vivo FLASH sparing effect of normal tissue toxicity observed with multiple proton FLASH irradiation systems. Importantly, multiple studies suggest little or no difference in tumor growth delay for proton FLASH when compared to conventional dose rate proton radiation. A discussion follows on future areas of development with a focus on the determination of the optimal parameters for maximizing the therapeutic ratio between tumor and normal tissue response and ultimately clinical translation of proton FLASH radiation.
Substances chimiques
Protons
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2039-2054Informations de copyright
© 2021 American Association of Physicists in Medicine.
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