Quantitative evaluation of posture control in rats with inferior olive lesions.

Animals Male Movement Olivary Nucleus / pathology Postural Balance Rats Rats, Wistar

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
13 10 2021
Historique:
received: 29 03 2021
accepted: 27 09 2021
entrez: 14 10 2021
pubmed: 15 10 2021
medline: 20 1 2022
Statut: epublish

Résumé

Impairment of inferior olivary neurons (IONs) affects whole-body movements and results in abnormal gait and posture. Because IONs are activated by unpredicted motion rather than regular body movements, the postural dysfunction caused by ION lesions is expected to involve factors other than simple loss of feedback control. In this study, we measured the postural movements of rats with pharmacological ION lesions (IO rats) trained to stand on their hindlimbs. The coordination of body segments as well as the distribution and frequency characteristics of center of mass (COM) motion were analyzed. We determined that the lesion altered the peak properties of the power spectrum density of the COM, whereas changes in coordination and COM distribution were minor. To investigate how the observed properties reflected changes in the control system, we constructed a mathematical model of the standing rats and quantitatively identified the control system. We found an increase in linear proportional control and a decrease in differential and nonlinear control in IO rats compared with intact rats. The dystonia-like changes in body stiffness explain the nature of the linear proportional and differential control, and a disorder in the internal model is one possible cause of the decrease in nonlinear control.

Identifiants

DOI: 10.1038/s41598-021-99785-w PMID: 34645901 PMC: PMC8514513
pubmed: 34645901
doi: 10.1038/s41598-021-99785-w
pii: 10.1038/s41598-021-99785-w
pmc: PMC8514513
doi:

Banques de données

Dryad
['10.5061/dryad.jwstqjq7x']

Types de publication

Evaluation Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

20362

Informations de copyright

© 2021. The Author(s).

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Auteurs

Tetsuro Funato (T)

Department of Mechanical Engineering and Intelligent Systems, The University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo, 182-8585, Japan. funato@uec.ac.jp.

Yota Sato (Y)

Department of Mechanical Engineering and Intelligent Systems, The University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo, 182-8585, Japan.

Yamato Sato (Y)

Department of Life Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, 153-8902, Japan.
Faculty of Creative Engineering, Chiba Institute of Technology, 2-1-1 Shibazono, Narashino, Chiba, 275-0023, Japan.

Soichiro Fujiki (S)

Department of Life Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, 153-8902, Japan.
Department of Physiology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsugagun, Tochigi, 321-0293, Japan.

Shinya Aoi (S)

Department of Aeronautics and Astronautics, Kyoto University, Kyoto daigaku-Katsura, Nishikyo-ku, Kyoto, 615-8540, Japan.

Kazuo Tsuchiya (K)

Department of Aeronautics and Astronautics, Kyoto University, Kyoto daigaku-Katsura, Nishikyo-ku, Kyoto, 615-8540, Japan.

Dai Yanagihara (D)

Department of Life Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, 153-8902, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Quantitative evaluation of posture control in...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Quantitative evaluation of posture control in...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Rhombencéphale › Myélencéphale › Moelle allongée › Noyau olivaire › Quantitative evaluation of posture control in...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Proprioception › Équilibre postural › Quantitative evaluation of posture control in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Quantitative evaluation of posture control in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Quantitative evaluation of posture control in...