The expression of human testis-specific actin capping protein predicts in vitro fertilization outcomes: A novel biomarker of sperm function for assisted reproductive technology.
actin capping protein
in vitro fertilization
male infertility
predictive marker
sperm function
Journal
Reproductive medicine and biology
ISSN: 1445-5781
Titre abrégé: Reprod Med Biol
Pays: Japan
ID NLM: 101213278
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
09
05
2021
revised:
29
07
2021
accepted:
01
08
2021
entrez:
14
10
2021
pubmed:
15
10
2021
medline:
15
10
2021
Statut:
epublish
Résumé
Sperm function tests do not adequately assess fertilization potential, and new indices are required. We have previously reported that human testis-specific actin capping proteins may be involved in both sperm morphology and function. This study aimed to determine whether testis-specific actin capping proteins can be a predictive marker of IVF success. Ninety-seven infertile couples who underwent IVF at an infertility clinic were included. Sperm were immunohistochemically stained to evaluate capping protein expression, and the percentage of sperms with normal staining was calculated. The relationship between actin capping protein expression and IVF outcomes was examined. The couples were divided into four groups according to the percentage of normally expressing actin capping protein as follows: ≥90% Group Ⅰ, 80%-90% Group Ⅱ, 70%-80% Group Ⅲ, and <70% Group Ⅳ. Multiple regression analysis showed a significant trend in fertilization rates across the 4 groups ( The human testis-specific actin capping protein may be a marker of male contributing factors that predict IVF outcomes.
Identifiants
pubmed: 34646082
doi: 10.1002/rmb2.12407
pii: RMB212407
pmc: PMC8499592
doi:
Types de publication
Journal Article
Langues
eng
Pagination
537-542Informations de copyright
© 2021 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine.
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest.
Références
J Cell Biol. 2006 Dec 18;175(6):947-55
pubmed: 17178911
Fertil Steril. 2014 Mar;101(3):633-4
pubmed: 24559617
Am J Reprod Immunol. 2019 Oct;82(4):e13170
pubmed: 31310689
Hum Reprod. 1997 Sep;12(9):1969-73
pubmed: 9363715
Nat Rev Mol Cell Biol. 2014 Oct;15(10):677-89
pubmed: 25207437
Urol Clin North Am. 2014 Feb;41(1):19-37
pubmed: 24286765
Nature. 2005 Mar 10;434(7030):234-8
pubmed: 15759005
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11493-11502
pubmed: 32393636
Fertil Steril. 1992 Oct;58(4):803-8
pubmed: 1426328
J Cell Biol. 1999 Dec 13;147(6):1287-98
pubmed: 10601341
Mol Hum Reprod. 2002 Jun;8(6):531-9
pubmed: 12029070
Hum Reprod. 2017 Mar 1;32(3):514-522
pubmed: 28104696
Hum Reprod. 2014 Jun;29(6):1225-37
pubmed: 24781426
Fertil Steril. 2011 Jun 30;95(8):2665-8
pubmed: 21549365
Mol Hum Reprod. 2002 Jan;8(1):16-23
pubmed: 11756565
Reprod Biol Endocrinol. 2018 Aug 24;16(1):81
pubmed: 30143014
Arch Androl. 1991 Sep-Oct;27(2):73-8
pubmed: 1953199
J Androl. 2006 May-Jun;27(3):326-34
pubmed: 16474012
Reprod Biol Endocrinol. 2015 Apr 26;13:37
pubmed: 25928197
PLoS One. 2012;7(5):e35195
pubmed: 22590500
Mol Biol Cell. 2014 Jul 15;25(14):2152-60
pubmed: 24829386
Reprod Biol Endocrinol. 2021 Jul 16;19(1):112
pubmed: 34271917
Fertil Steril. 2013 Sep;100(3):697-703
pubmed: 23731996
Fertil Steril. 1990 Jun;53(6):1055-9
pubmed: 2351228
Reprod Med Biol. 2019 May 24;18(3):234-240
pubmed: 31312101
J Cell Biol. 1995 Jan;128(1-2):61-70
pubmed: 7822423
Cytoskeleton (Hoboken). 2011 Nov;68(11):596-602
pubmed: 22002930
Am J Reprod Immunol. 1997 Apr;37(4):291-9
pubmed: 9161635
Fertil Steril. 1986 May;45(5):665-70
pubmed: 3699171