Multiple Sclerosis and SARS-CoV-2: Has the Interplay Started?
COVID-19
EBV—Epstein-Barr Virus
SARS-CoV-2
multiple sclerosis
neuroinflammation
vaccine
virus
virus-host interactions
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
08
08
2021
accepted:
03
09
2021
entrez:
14
10
2021
pubmed:
15
10
2021
medline:
25
2
2023
Statut:
epublish
Résumé
Current knowledge on Multiple Sclerosis (MS) etiopathogenesis encompasses complex interactions between the host's genetic background and several environmental factors that result in dysimmunity against the central nervous system. An old-aged association exists between MS and viral infections, capable of triggering and sustaining neuroinflammation through direct and indirect mechanisms. The novel Coronavirus, SARS-CoV-2, has a remarkable, and still not fully understood, impact on the immune system: the occurrence and severity of both acute COVID-19 and post-infectious chronic illness (long COVID-19) largely depends on the host's response to the infection, that echoes several aspects of MS pathobiology. Furthermore, other MS-associated viruses, such as the Epstein-Barr Virus (EBV) and Human Endogenous Retroviruses (HERVs), may enhance a mechanistic interplay with the novel Coronavirus, with the potential to interfere in MS natural history. Studies on COVID-19 in people with MS have helped clinicians in adjusting therapeutic strategies during the pandemic; similar efforts are being made for SARS-CoV-2 vaccination campaigns. In this Review, we look over 18 months of SARS-CoV-2 pandemic from the perspective of MS: we dissect neuroinflammatory and demyelinating mechanisms associated with COVID-19, summarize pathophysiological crossroads between MS and SARS-CoV-2 infection, and discuss present evidence on COVID-19 and its vaccination in people with MS.
Identifiants
pubmed: 34646278
doi: 10.3389/fimmu.2021.755333
pmc: PMC8503550
doi:
Substances chimiques
COVID-19 Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
755333Informations de copyright
Copyright © 2021 Bellucci, Rinaldi, Buscarinu, Reniè, Bigi, Pellicciari, Morena, Romano, Marrone, Mechelli, Salvetti and Ristori.
Déclaration de conflit d'intérêts
MS received research support and consulting fees from Biogen, Merck, Novartis, Roche, Sanofi, Teva. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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