BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators.
Animals
Apoptosis
/ drug effects
Cell Cycle
/ drug effects
Cell Cycle Proteins
/ drug effects
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Computational Biology
Cyclin-Dependent Kinases
/ metabolism
DNA Damage
/ drug effects
Databases, Genetic
Disease Models, Animal
Female
Gene Expression
/ genetics
Gene Expression Regulation, Neoplastic
/ genetics
Humans
Mice
Mice, Nude
Phosphorylation
Signal Transduction
/ drug effects
Transcriptome
/ genetics
Triple Negative Breast Neoplasms
/ drug therapy
Xenograft Model Antitumor Assays
bcl-X Protein
/ genetics
BCL-XL
MET
cancer mouse model
cell cycle regulators
triple-negative breast cancer
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
03
2021
accepted:
23
08
2021
entrez:
14
10
2021
pubmed:
15
10
2021
medline:
8
2
2022
Statut:
epublish
Résumé
Cell cycle regulators are frequently altered in Triple-Negative Breast Cancer (TNBC). Emerging agents targeting these signals offer the possibility to design new combinatorial therapies. However, preclinical models that recapitulate TNBC primary resistance and heterogeneity are essential to evaluate the potency of these combined treatments.
Identifiants
pubmed: 34646365
doi: 10.7150/thno.60503
pii: thnov11p9180
pmc: PMC8490507
doi:
Substances chimiques
BCL2L1 protein, human
0
Cell Cycle Proteins
0
bcl-X Protein
0
Cyclin-Dependent Kinases
EC 2.7.11.22
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9180-9197Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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