Protective effects of tea extracts against alcoholic fatty liver disease in mice via modulating cytochrome P450 2E1 expression and ameliorating oxidative damage.
alcohol metabolism
alcoholic fatty liver disease
antioxidant activity
lipid accumulation
tea
Journal
Food science & nutrition
ISSN: 2048-7177
Titre abrégé: Food Sci Nutr
Pays: United States
ID NLM: 101605473
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
08
03
2021
revised:
01
07
2021
accepted:
11
07
2021
entrez:
14
10
2021
pubmed:
15
10
2021
medline:
15
10
2021
Statut:
epublish
Résumé
The alcoholic fatty liver disease (AFLD) has been a severe public health problem. Oxidative stress is involved in the initiation and progression of AFLD. Tea is a popular beverage worldwide with strong antioxidant activity. In this research, our purpose is to explore and compare the effects of 12 selected teas on AFLD. The ethanol liquid diet was used to feed the mice, and 12 tea extracts were administrated at 200 mg/kg body weight every day for 4 weeks. The results showed that the application of several tea extracts exhibited different inhibitory effects on lipid accumulation induced by sub-acute alcohol consumption based on the determination of triglyceride concentration and the histological alteration in the liver. In addition, several teas significantly decreased serum alanine aminotransferase and aspartate aminotransferase activities, inhibited the cytochrome P450 2E1 expression, and promoted alcohol metabolism (
Identifiants
pubmed: 34646532
doi: 10.1002/fsn3.2526
pii: FSN32526
pmc: PMC8498066
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5626-5640Informations de copyright
© 2021 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.
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