Globin Digest Improves Visceral Adiposity Through UCP1 Upregulation in Diet-Induced Obese Zebrafish and Mice.
comparative transcriptomics
metabolic syndrome
natural product
obesity
oligopeptides
zebrafish
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
01
2021
accepted:
12
08
2021
entrez:
14
10
2021
pubmed:
15
10
2021
medline:
15
10
2021
Statut:
epublish
Résumé
Globin digest (GD), a bioactive oligopeptide derived from porcine hemoglobin proteins, has been demonstrated to have beneficial effects on improving postprandial hyperlipidemia, hyperglycemia, and liver injury. We previously reported the lipid-lowering effects of GD using a zebrafish obesogenic test. Here, we sought to evaluate the effect of GD on visceral adiposity and the underlying molecular mechanisms using zebrafish and mouse obesity models. GD ameliorated dyslipidemia and suppressed the accumulation of visceral adipose tissue (VAT) in adult obese zebrafish. Transcriptomic analysis by RNA sequencing of GD-treated adult zebrafish revealed that GD upregulated UCP1-related pathways. Further, we performed mouse experiments and found that GD intake (2 mg/g body weight/day) was associated with lowered plasma triglyceride and total cholesterol levels, decreased VAT accumulation, and improved adipocyte hypertrophy with the upregulation of
Identifiants
pubmed: 34646848
doi: 10.3389/fnut.2021.650975
pmc: PMC8502801
doi:
Types de publication
Journal Article
Langues
eng
Pagination
650975Informations de copyright
Copyright © 2021 Zang, Shimada, Nakayama, Matsuoka, Kim, Chu, Juneja, Tsuruta, Sasakawa, Kuroyanagi and Nishimura.
Déclaration de conflit d'intérêts
YK, D-CC, and LJ were employees of Rohto Pharmaceutical Co., Ltd., a pharmaceutical company. RT and YSa are employees of MG Pharma Inc., a pharmaceutical company (a member of the Rohto Pharmaceutical group). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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