Site-specific

Cancer Cell biology Proteomics

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
22 Oct 2021
Historique:
received: 02 04 2021
revised: 28 07 2021
accepted: 21 09 2021
entrez: 14 10 2021
pubmed: 15 10 2021
medline: 15 10 2021
Statut: epublish

Résumé

Integrin alpha 2 (ITGA2) promotes cancer metastasis through selective adhesion to ECM proteins; however, the specific contribution of integrin glycosylation remains uncertain. We provide evidence that ITGA2 is a highly glycosylated transmembrane protein expressed in ovarian cancer tissue and cell lines. In-depth glycoproteomics identified predominant

Identifiants

pubmed: 34646995
doi: 10.1016/j.isci.2021.103168
pii: S2589-0042(21)01136-6
pmc: PMC8501769
doi:

Types de publication

Journal Article

Langues

eng

Pagination

103168

Informations de copyright

© 2021 The Author(s).

Déclaration de conflit d'intérêts

The authors declared no potential conflicts of interest.

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Auteurs

Yen-Lin Huang (YL)

Ovarian Cancer Research, Department of Biomedicine, University Hospital Basel and University of Basel, Hebelstrasse 20, Basel 4031, Switzerland.

Ching-Yeu Liang (CY)

Ovarian Cancer Research, Department of Biomedicine, University Hospital Basel and University of Basel, Hebelstrasse 20, Basel 4031, Switzerland.

Vera Labitzky (V)

Institute of Anatomy and Experimental Morphology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg20246, Germany.

Danilo Ritz (D)

Proteomics Core Facility, Biozentrum, University of Basel, Basel4056, Switzerland.

Tiago Oliveira (T)

Institute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD4222, Australia.

Cécile Cumin (C)

Ovarian Cancer Research, Department of Biomedicine, University Hospital Basel and University of Basel, Hebelstrasse 20, Basel 4031, Switzerland.

Manuela Estermann (M)

Adolphe Merkle Institute, University of Fribourg, Fribourg1700, Switzerland.

Tobias Lange (T)

Institute of Anatomy and Experimental Morphology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg20246, Germany.

Arun V Everest-Dass (AV)

Institute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD4222, Australia.

Francis Jacob (F)

Ovarian Cancer Research, Department of Biomedicine, University Hospital Basel and University of Basel, Hebelstrasse 20, Basel 4031, Switzerland.

Classifications MeSH