Excimer laser atherectomy combined with drug-coated balloon versus drug-eluting balloon angioplasty for the treatment of infrapopliteal arterial revascularization in ischemic diabetic foot: 24-month outcomes.
Angioplasty, Balloon
/ adverse effects
Atherectomy
/ adverse effects
Coated Materials, Biocompatible
Diabetes Mellitus
Diabetic Foot
/ therapy
Femoral Artery
Humans
Lasers, Excimer
/ therapeutic use
Peripheral Arterial Disease
/ surgery
Popliteal Artery
/ surgery
Retrospective Studies
Treatment Outcome
Vascular Patency
Angioplasty
Balloon
Diabetic foot
Excimer
Lasers
Journal
Lasers in medical science
ISSN: 1435-604X
Titre abrégé: Lasers Med Sci
Pays: England
ID NLM: 8611515
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
15
03
2021
accepted:
29
07
2021
pubmed:
15
10
2021
medline:
5
4
2022
entrez:
14
10
2021
Statut:
ppublish
Résumé
There are few studies on excimer laser (308 nm) atherectomy in the treatment of infrapopliteal artery disease. The purpose of this retrospective clinical study was to assess the efficacy and safety of excimer laser atherectomy (ELA) in combination with adjuvant drug-coated balloon angioplasty (DCB) compared to DCB for infrapopliteal arterial revascularization in patients with ischemic diabetic foot. From September 2018 to February 2019, a total of 79 patients with diabetic foot were treated for infrapopliteal arterial revascularization at Tianjin First Central Hospital (Tianjin, China). In this project, 35 patients were treated with ELA combined with DCB angioplasty, and 44 patients were treated with DCB angioplasty. The patients' baseline characteristics were similar between the 2 groups. The primary efficacy endpoints through 24 months were clinically driven target lesion revascularization (CD-TLR), wound healing rate, major amputation rate, and target vessel patency rate. The primary safety endpoint through 24 months was all-cause mortality. The primary efficacy results at 24 months of ELA + DCB versus DCB were CD-TLR of 14.3% versus 34.1% (p = 0.044), wound healing rate of 88.6% versus 65.9% (p = 0.019), target vessel patency rate of 80.0% versus 52.3% (p = 0.010), and major amputations rate of 5.7% versus 22.7% (p = 0.036). The safety signal at 24 months of all-cause mortality rate was 2.9% for ELA + DCB group and 4.5% for DCB group (p = 0.957). ELA combined with DCB angioplasty is more effective than DCB in the treatment of infrapopliteal artery disease in patients with ischemic diabetic foot, which can improve the wound healing rate and target vessel patency rate. There was no statistical difference in the safety results between the two groups.
Identifiants
pubmed: 34647190
doi: 10.1007/s10103-021-03393-z
pii: 10.1007/s10103-021-03393-z
doi:
Substances chimiques
Coated Materials, Biocompatible
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1531-1537Subventions
Organisme : Tianjin Science and Technology Committee
ID : 18ZXDBSY00110
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.
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