mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
03 Dec 2021
03 Dec 2021
Historique:
pubmed:
15
10
2021
medline:
15
12
2021
entrez:
14
10
2021
Statut:
ppublish
Résumé
The durability of immune memory after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccination remains unclear. In this study, we longitudinally profiled vaccine responses in SARS-CoV-2–naïve and –recovered individuals for 6 months after vaccination. Antibodies declined from peak levels but remained detectable in most subjects at 6 months. By contrast, mRNA vaccines generated functional memory B cells that increased from 3 to 6 months postvaccination, with the majority of these cells cross-binding the Alpha, Beta, and Delta variants. mRNA vaccination further induced antigen-specific CD4
Identifiants
pubmed: 34648302
doi: 10.1126/science.abm0829
pmc: PMC9284784
mid: NIHMS1819710
doi:
Substances chimiques
COVID-19 Vaccines
0
mRNA Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
abm0829Subventions
Organisme : NIAMS NIH HHS
ID : T32 AR076951
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI142638
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI152236
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI070077
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009140
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI045008
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI082630
Pays : United States
Organisme : NHLBI NIH HHS
ID : R38 HL143613
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI108545
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI105343
Pays : United States
Organisme : NICHD NIH HHS
ID : R61 HD105594
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI055400
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI155577
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI149680
Pays : United States
Commentaires et corrections
Type : UpdateOf
Type : CommentIn
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