Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease.

Aged Aging / pathology Alzheimer Disease / pathology Atrophy Brain / diagnostic imaging Cognition Cognitive Dysfunction / diagnostic imaging Cohort Studies Female Humans Magnetic Resonance Imaging / methods Male Middle Aged Neuropsychological Tests Parkinson Disease / complications
Alzheimer's disease Brain Age MRI Parkinson's disease Pattern classification

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
01 2022
Historique:
received: 07 03 2021
revised: 27 08 2021
accepted: 31 08 2021
pubmed: 15 10 2021
medline: 19 2 2022
entrez: 14 10 2021
Statut: ppublish

Résumé

Recently, it was shown that patients with Parkinson's disease (PD) who exhibit an "Alzheimer's disease (AD)-like" pattern of brain atrophy are at greater risk for future cognitive decline. This study aimed to investigate whether this association is domain-specific and whether atrophy associated with brain aging also relates to cognitive impairment in PD. SPARE-AD, an MRI index capturing AD-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort. All patients underwent an extensive neuropsychological test battery. Patients diagnosed with mild cognitive impairment or dementia were found to have higher SPARE-AD scores as compared to patients with normal cognition and healthy controls. All patient groups showed increased brain age. SPARE-AD predicted impairment in memory, language and executive functions, whereas advanced brain age was associated with deficits in attention and working memory. Data suggest that SPARE-AD and brain age are differentially related to domain-specific cognitive decline in PD. The underlying pathomechanisms remain to be determined.

Identifiants

DOI: 10.1016/j.neurobiolaging.2021.08.020 PMID: 34649002
pubmed: 34649002
pii: S0197-4580(21)00274-8
doi: 10.1016/j.neurobiolaging.2021.08.020
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

31-42

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Daniel Charissé (D)

Department of Neurology, Goethe University, Frankfurt am Main, Germany; Brain Imaging Center, Goethe University, Frankfurt am Main, Germany.

Guray Erus (G)

Department of Radiology, Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.

Raymond Pomponio (R)

Department of Radiology, Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.

Martin Gorges (M)

Germany Institute of Medical Technology, Brandenburg University of Technology Cottbus - Senftenberg, Cottbus, Germany.

Nele Schmidt (N)

Department of Neurology, Christian Albrecht University, Kiel, Germany; Department of Neurology, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Christine Schneider (C)

Department of Neurology and Clinical Neurophysiology, University Hospital Augsburg, Augsburg, Germany; Division of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.

Inga Liepelt-Scarfone (I)

Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Tübingen, Germany; Studienzentrum Stuttgart, IB Hochschule Stuttgart, Stuttgart, Germany.

Oliver Riedel (O)

Leibniz Institute for Prevention Research and Epidemiology, Bremen, Germany.

Kathrin Reetz (K)

Department of Neurology, University Hospital, RWTH Aachen University, Aachen, Germany; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Aachen, Germany.

Jörg B Schulz (JB)

Department of Neurology, University Hospital, RWTH Aachen University, Aachen, Germany; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Aachen, Germany.

Daniela Berg (D)

Department of Neurology, Christian Albrecht University, Kiel, Germany; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Tübingen, Germany.

Alexander Storch (A)

Division of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany; Department of Neurology, University of Rostock, Rostock, Germany; German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Rostock, Germany.

Karsten Witt (K)

Department of Neurology, Christian Albrecht University, Kiel, Germany; Department of Neurology, Carl von Ossietzky University Oldenburg, Oldenburg, Germany; Research Center Neurosensory Science, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Richard Dodel (R)

Department of Neuro-Geriatrics, University Hospital Essen, Essen, Germany; Department of Neurology, Philipps University Marburg, Marburg, Germany.

Elke Kalbe (E)

Medical Psychology - Neuropsychology and Gender Studies & Center for Neuropsychological Diagnostics and Intervention (CeNDI), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Jan Kassubek (J)

Department of Neurology, University of Ulm, Ulm, Germany.

Rüdiger Hilker-Roggendorf (R)

Department of Neurology, Goethe University, Frankfurt am Main, Germany; Department of Neurology, Klinikum Vest, Knappschaftskrankenhaus Recklinghausen, Recklinghausen, Germany.

Simon Baudrexel (S)

Department of Neurology, Goethe University, Frankfurt am Main, Germany; Brain Imaging Center, Goethe University, Frankfurt am Main, Germany. Electronic address: simon.baudrexel@kgu.de.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Brain age and Alzheimer's-like atrophy are...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Brain age and Alzheimer's-like atrophy are...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Brain age and Alzheimer's-like atrophy are...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Atrophie › Brain age and Alzheimer's-like atrophy are...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Brain age and Alzheimer's-like atrophy are...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Brain age and Alzheimer's-like atrophy are...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Brain age and Alzheimer's-like atrophy are...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Brain age and Alzheimer's-like atrophy are...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Brain age and Alzheimer's-like atrophy are...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Brain age and Alzheimer's-like atrophy are...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Brain age and Alzheimer's-like atrophy are...
questionsmedicales.fr › Disciplines et activités comportementales › Tests psychologiques › Tests neuropsychologiques › Brain age and Alzheimer's-like atrophy are...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Brain age and Alzheimer's-like atrophy are...