Metabolomic differences in lung function metrics: evidence from two cohorts.

Adult Forced Expiratory Volume Humans Lung Male Prospective Studies Respiratory Function Tests Vital Capacity
clinical epidemiology oxidative stress respiratory measurement systemic disease and lungs

Journal

Thorax
ISSN: 1468-3296
Titre abrégé: Thorax
Pays: England
ID NLM: 0417353

Informations de publication

Date de publication:
09 2022
Historique:
received: 25 11 2020
accepted: 18 09 2021
pubmed: 16 10 2021
medline: 20 8 2022
entrez: 15 10 2021
Statut: ppublish

Résumé

The biochemical mechanisms underlying lung function are incompletely understood. To identify and validate the plasma metabolome of lung function using two independent adult cohorts: discovery-the European Prospective Investigation into Cancer-Norfolk (EPIC-Norfolk, n=10 460) and validation-the VA Normative Aging Study (NAS) metabolomic cohort (n=437). We ran linear regression models for 693 metabolites to identify associations with forced expiratory volume in one second (FEV Of 156 metabolites that associated with FEV The validation of metabolites associated with respiratory function can help to better understand mechanisms of lung health and may assist the development of biomarkers.

Identifiants

DOI: 10.1136/thoraxjnl-2020-216639 PMID: 34650005 PMC: PMC9008068
pubmed: 34650005
pii: thoraxjnl-2020-216639
doi: 10.1136/thoraxjnl-2020-216639
pmc: PMC9008068
mid: NIHMS1766615
doi:

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

919-928

Subventions

Organisme : Medical Research Council
ID : MC_UU_00006/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL123915
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141826
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_12015/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N003284/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C864/A14136
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0401527
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L00002/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1000143
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 14136
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : K01 HL146980
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL132825
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023268
Pays : United States

Informations de copyright

© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Auteurs

Rachel S Kelly (RS)

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA hprke@channing.harvard.edu.

Isobel D Stewart (ID)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Haley Bayne (H)

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Priyadarshini Kachroo (P)

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Avron Spiro (A)

Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), 150 South Huntington Avenue, Boston, MA 02130, USA, VA Boston Healthcare System, Boston, MA 02130, USA.
Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA.
Department of Psychiatry, Boston University School of Medicine, Boston, MA 02118, USA.

Pantel Vokonas (P)

VA Normative Aging Study, Boston University School of Medicine, Boston, MA 02118, USA.

David Sparrow (D)

VA Normative Aging Study, Boston University School of Medicine, Boston, MA 02118, USA.

Scott T Weiss (ST)

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Hanna M Knihtilä (HM)

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Augusto A Litonjua (AA)

Division of Pediatric Pulmonary Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.

Nicholas J Wareham (NJ)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Claudia Langenberg (C)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Jessica A Lasky-Su (JA)

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Metabolomic differences in lung function...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Ventilation pulmonaire › Volume expiratoire maximal par seconde › Metabolomic differences in lung function...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Metabolomic differences in lung function...
questionsmedicales.fr › Appareil respiratoire › Poumon › Metabolomic differences in lung function...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Metabolomic differences in lung function...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic respiratoire › Tests de la fonction respiratoire › Metabolomic differences in lung function...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Capacité pulmonaire totale › Capacité vitale › Metabolomic differences in lung function...