Pain sensing neurons promote tissue regeneration in adult mice.
Journal
NPJ Regenerative medicine
ISSN: 2057-3995
Titre abrégé: NPJ Regen Med
Pays: United States
ID NLM: 101699846
Informations de publication
Date de publication:
14 Oct 2021
14 Oct 2021
Historique:
received:
14
02
2021
accepted:
14
09
2021
entrez:
15
10
2021
pubmed:
16
10
2021
medline:
16
10
2021
Statut:
epublish
Résumé
Tissue repair after injury in adult mammals, usually results in scarring and loss of function in contrast to lower vertebrates such as the newt and zebrafish that regenerate. Understanding the regulatory processes that guide the outcome of tissue repair is therefore a concerning challenge for regenerative medicine. In multiple regenerative animal species, the nerve dependence of regeneration is well established, but the nature of the innervation required for tissue regeneration remains largely undefined. Using our model of induced adipose tissue regeneration in adult mice, we demonstrate here that nociceptive nerves promote regeneration and their removal impairs tissue regeneration. We also show that blocking the receptor for the nociceptive neuropeptide calcitonin gene-related peptide (CGRP) inhibits regeneration, whereas CGRP administration induces regeneration. These findings reveal that peptidergic nociceptive neurons are required for adult mice tissue regeneration.
Identifiants
pubmed: 34650070
doi: 10.1038/s41536-021-00175-7
pii: 10.1038/s41536-021-00175-7
pmc: PMC8516997
doi:
Types de publication
Journal Article
Langues
eng
Pagination
63Subventions
Organisme : Fondation pour la Recherche Médicale (Foundation for Medical Research in France)
ID : FDT201904008033
Informations de copyright
© 2021. The Author(s).
Références
Clin J Pain. 2004 Jul-Aug;20(4):227-39
pubmed: 15218407
Am J Physiol Regul Integr Comp Physiol. 2006 Nov;291(5):R1243-55
pubmed: 16809481
N Engl J Med. 2004 Mar 11;350(11):1104-10
pubmed: 15014183
Biomed Pharmacother. 2008 Jul-Aug;62(6):352-9
pubmed: 18430544
Pharmacol Rev. 2011 Dec;63(4):860-81
pubmed: 21969325
Brain Res. 2003 Feb 28;964(2):302-5
pubmed: 12576191
Anesth Analg. 2013 May;116(5):1057-1062
pubmed: 23477963
Rom J Anaesth Intensive Care. 2018 Apr;25(1):19-23
pubmed: 29756058
Curr Top Dev Biol. 2014;108:217-46
pubmed: 24512711
J Exp Biol. 1987 Sep;132:79-91
pubmed: 3323408
Methods Enzymol. 2014;537:199-225
pubmed: 24480348
Brain Res Dev Brain Res. 1998 Jun 15;108(1-2):239-54
pubmed: 9693800
Gut. 2018 Apr;67(4):600-602
pubmed: 28642332
J Physiol. 1985 Jul;364:1-18
pubmed: 4032293
Neuropharmacology. 2015 Jun;93:267-73
pubmed: 25721395
BMC Dev Biol. 2014 Dec 31;14:49
pubmed: 25551555
Sci Transl Med. 2014 Dec 3;6(265):265sr6
pubmed: 25473038
Eur J Pharmacol. 1987 Oct 27;142(3):355-8
pubmed: 3501377
JBMR Plus. 2019 Feb 27;3(4):e10172
pubmed: 31044187
J Pharmacol Exp Ther. 2005 Aug;314(2):596-602
pubmed: 15860573
Front Neuroanat. 2014 Apr 22;8:21
pubmed: 24795573
Anesth Analg. 2015 Jun;120(6):1242-53
pubmed: 25988634
Cell Tissue Res. 2002 Mar;307(3):281-91
pubmed: 11904764
Science. 2011 Feb 25;331(6020):1078-80
pubmed: 21350179
Molecules. 2016 Jun 18;21(6):
pubmed: 27322240
Antioxid Redox Signal. 2016 Feb 20;24(6):299-311
pubmed: 26442784
Metabol Open. 2020 Oct 08;8:100060
pubmed: 33089134
Nat Rev Neurosci. 2005 Jul;6(7):507-20
pubmed: 15995722
Anesth Analg. 1993 May;76(5):1072-8
pubmed: 8484510
J Cell Biochem. 2011 Oct;112(10):2748-58
pubmed: 21678472
Adv Exp Med Biol. 2003;521:69-76
pubmed: 12617565
Dev Cell. 2015 Aug 24;34(4):387-99
pubmed: 26256209
Front Integr Neurosci. 2012 Oct 17;6:94
pubmed: 23087627
Sci Rep. 2018 Aug 15;8(1):12170
pubmed: 30111876
Cell Rep. 2018 Sep 25;24(13):3383-3392.e5
pubmed: 30257200
Trends Immunol. 2017 Jan;38(1):5-19
pubmed: 27793571
Sci Immunol. 2020 Aug 28;5(50):
pubmed: 32859683
Invest Ophthalmol Vis Sci. 2012 Dec 17;53(13):8280-7
pubmed: 23154458
Sci Rep. 2016 Jun 14;6:27724
pubmed: 27296555
Biochim Biophys Acta. 2013 Jul;1833(7):1680-91
pubmed: 22982061
J Orthop Res. 2018 May;36(5):1444-1455
pubmed: 29227562
Pain. 2014 Jan;155(1):168-178
pubmed: 24076162
Nature. 2013 Jul 11;499(7457):228-32
pubmed: 23760480
J Neurosci. 2011 Jul 13;31(28):10119-27
pubmed: 21752988
Neurosci Biobehav Rev. 2000 Dec;24(8):843-54
pubmed: 11118609
Curr Opin Pharmacol. 2009 Feb;9(1):3-8
pubmed: 19157985
J Anat. 2012 Jan;220(1):3-12
pubmed: 22066944
J Cell Sci. 1992 Dec;103 ( Pt 4):931-42
pubmed: 1362571
Cell. 2014 Jan 16;156(1-2):20-44
pubmed: 24439368
Pain. 2004 Sep;111(1-2):38-50
pubmed: 15327807