Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes.


Journal

NPJ digital medicine
ISSN: 2398-6352
Titre abrégé: NPJ Digit Med
Pays: England
ID NLM: 101731738

Informations de publication

Date de publication:
14 Oct 2021
Historique:
received: 10 05 2021
accepted: 09 08 2021
entrez: 15 10 2021
pubmed: 16 10 2021
medline: 16 10 2021
Statut: epublish

Résumé

Physical mobility is essential to health, and patients often rate it as a high-priority clinical outcome. Digital mobility outcomes (DMOs), such as real-world gait speed or step count, show promise as clinical measures in many medical conditions. However, current research is nascent and fragmented by discipline. This scoping review maps existing evidence on the clinical utility of DMOs, identifying commonalities across traditional disciplinary divides. In November 2019, 11 databases were searched for records investigating the validity and responsiveness of 34 DMOs in four diverse medical conditions (Parkinson's disease, multiple sclerosis, chronic obstructive pulmonary disease, hip fracture). Searches yielded 19,672 unique records. After screening, 855 records representing 775 studies were included and charted in systematic maps. Studies frequently investigated gait speed (70.4% of studies), step length (30.7%), cadence (21.4%), and daily step count (20.7%). They studied differences between healthy and pathological gait (36.4%), associations between DMOs and clinical measures (48.8%) or outcomes (4.3%), and responsiveness to interventions (26.8%). Gait speed, step length, cadence, step time and step count exhibited consistent evidence of validity and responsiveness in multiple conditions, although the evidence was inconsistent or lacking for other DMOs. If DMOs are to be adopted as mainstream tools, further work is needed to establish their predictive validity, responsiveness, and ecological validity. Cross-disciplinary efforts to align methodology and validate DMOs may facilitate their adoption into clinical practice.

Identifiants

pubmed: 34650191
doi: 10.1038/s41746-021-00513-5
pii: 10.1038/s41746-021-00513-5
pmc: PMC8516969
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

149

Informations de copyright

© 2021. The Author(s).

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Auteurs

Ashley Polhemus (A)

Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland. ashley.polhemus@uzh.ch.

Laura Delgado Ortiz (LD)

ISGlobal, Barcelona, Spain.
Universitat Pompeu Fabra, Barcelona, Spain.
CIBER Epidemiología y Salud Pública, Barcelona, Spain.

Gavin Brittain (G)

Department of Neuroscience and Sheffield NIHR Translational Neuroscience BRC, Sheffield Teaching Hospitals NHS Foundation Trust & University of Sheffield, Sheffield, England.

Nikolaos Chynkiamis (N)

Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University Newcastle, Newcastle, UK.

Francesca Salis (F)

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Heiko Gaßner (H)

Department of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany.

Michaela Gross (M)

Department of Clinical Gerontology, Robert-Bosch-Hospital, Stuttgart, Germany.

Cameron Kirk (C)

Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Rachele Rossanigo (R)

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Kristin Taraldsen (K)

Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.

Diletta Balta (D)

Department of Electronics and Telecommunications, Politecnico di Torino, Torino, Italy.

Sofie Breuls (S)

Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.
Department of Respiratory Diseases, University hospitals Leuven, Leuven, Belgium.

Sara Buttery (S)

National Heart and Lung Institute, Imperial College London, London, UK.

Gabriela Cardenas (G)

ISGlobal, Barcelona, Spain.
Universitat Pompeu Fabra, Barcelona, Spain.
CIBER Epidemiología y Salud Pública, Barcelona, Spain.

Christoph Endress (C)

Department of Clinical Gerontology, Robert-Bosch-Hospital, Stuttgart, Germany.

Julia Gugenhan (J)

Department of Clinical Gerontology, Robert-Bosch-Hospital, Stuttgart, Germany.

Alison Keogh (A)

Insight Centre for Data Analytics, University College Dublin, Dublin, Ireland.

Felix Kluge (F)

Department of Artificial Intelligence in Biomedical Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Sarah Koch (S)

ISGlobal, Barcelona, Spain.
Universitat Pompeu Fabra, Barcelona, Spain.
CIBER Epidemiología y Salud Pública, Barcelona, Spain.

M Encarna Micó-Amigo (ME)

Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Corinna Nerz (C)

Department of Clinical Gerontology, Robert-Bosch-Hospital, Stuttgart, Germany.

Chloé Sieber (C)

Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.

Parris Williams (P)

National Heart and Lung Institute, Imperial College London, London, UK.

Ronny Bergquist (R)

Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.

Magda Bosch de Basea (M)

ISGlobal, Barcelona, Spain.
Universitat Pompeu Fabra, Barcelona, Spain.
CIBER Epidemiología y Salud Pública, Barcelona, Spain.

Ellen Buckley (E)

Insigneo Institute, Department of Mechanical Engineering, University of Sheffield, Sheffield, UK.

Clint Hansen (C)

Department of Neurology, University Medical Center Schleswig-Holstein, Kiel, Germany.

A Stefanie Mikolaizak (AS)

Department of Clinical Gerontology, Robert-Bosch-Hospital, Stuttgart, Germany.

Lars Schwickert (L)

Department of Clinical Gerontology, Robert-Bosch-Hospital, Stuttgart, Germany.

Kirsty Scott (K)

Insigneo Institute, Department of Mechanical Engineering, University of Sheffield, Sheffield, UK.

Sabine Stallforth (S)

Department of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany.

Janet van Uem (J)

Department of Neurology, University Medical Center Schleswig-Holstein, Kiel, Germany.

Beatrix Vereijken (B)

Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.

Andrea Cereatti (A)

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Department of Electronics and Telecommunications, Politecnico di Torino, Torino, Italy.

Heleen Demeyer (H)

Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.
Department of Respiratory Diseases, University hospitals Leuven, Leuven, Belgium.
Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium.

Nicholas Hopkinson (N)

National Heart and Lung Institute, Imperial College London, London, UK.

Walter Maetzler (W)

Department of Neurology, University Medical Center Schleswig-Holstein, Kiel, Germany.

Thierry Troosters (T)

Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.
Department of Respiratory Diseases, University hospitals Leuven, Leuven, Belgium.

Ioannis Vogiatzis (I)

Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University Newcastle, Newcastle, UK.

Alison Yarnall (A)

Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Clemens Becker (C)

Department of Clinical Gerontology, Robert-Bosch-Hospital, Stuttgart, Germany.

Judith Garcia-Aymerich (J)

ISGlobal, Barcelona, Spain.
Universitat Pompeu Fabra, Barcelona, Spain.
CIBER Epidemiología y Salud Pública, Barcelona, Spain.

Letizia Leocani (L)

Department of Neurology, San Raffaele University, Milan, Italy.

Claudia Mazzà (C)

Insigneo Institute, Department of Mechanical Engineering, University of Sheffield, Sheffield, UK.

Lynn Rochester (L)

Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Basil Sharrack (B)

Department of Neuroscience and Sheffield NIHR Translational Neuroscience BRC, Sheffield Teaching Hospitals NHS Foundation Trust & University of Sheffield, Sheffield, England.

Anja Frei (A)

Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.

Milo Puhan (M)

Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.

Classifications MeSH