Low Expression of Stanniocalcin 1 (STC-1) Protein Is Associated With Poor Clinicopathologic Features of Endometrial Cancer.
Aged
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Biomarkers, Tumor
/ metabolism
Cohort Studies
Combined Modality Therapy
Diabetes Mellitus, Type 2
/ drug therapy
Endometrial Neoplasms
/ metabolism
Female
Follow-Up Studies
Glycoproteins
/ metabolism
Humans
Lymph Node Excision
Middle Aged
Obesity
/ physiopathology
Pilot Projects
Prognosis
disease-specific survival
endometrioid carcinoma
metformin
stanniocalcin-1
type 2 diabetes mellitus
uterine cancer
Journal
Pathology oncology research : POR
ISSN: 1532-2807
Titre abrégé: Pathol Oncol Res
Pays: Switzerland
ID NLM: 9706087
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
07
2021
accepted:
13
09
2021
entrez:
15
10
2021
pubmed:
16
10
2021
medline:
8
2
2022
Statut:
epublish
Résumé
Stanniocalcin-1 (STC-1) is a glycoprotein hormone involved in diverse biological processes, including regulation of calcium phosphate homeostasis, cell proliferation, apoptosis, inflammation, oxidative stress responses, and cancer development. The role of STC-1 in endometrial cancer (EC) is yet to be elucidated. In this study, we investigated the protein expression pattern of STC-1 in a tissue microarray (TMA) cohort of hysterectomy specimens from 832 patients with EC. We then evaluated the prognostic value of STC-1 expression regarding the clinicopathologic features and patients survival over a period of 140 months. Our results revealed that in EC tissue samples, STC-1 is mainly localized in the endometrial epithelium, although some expression was also observed in the stroma. Decreased STC-1 expression was associated with factors relating to a worse prognosis, such as grade 3 endometrioid tumors (
Identifiants
pubmed: 34650342
doi: 10.3389/pore.2021.1609936
pii: 1609936
pmc: PMC8505533
doi:
Substances chimiques
Biomarkers, Tumor
0
Glycoproteins
0
teleocalcin
76687-96-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1609936Informations de copyright
Copyright © 2021 Khatun, Urpilainen, Ahtikoski, Arffman, Pasanen, Puistola, Tapanainen, Andersson, Butzow, Loukovaara and Piltonen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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