ITIH5 shows tumor suppressive properties in cervical cancer cells grown as multicellular tumor spheroids.

3D cell culture Cervical carcinogenesis ITIH5 human papillomavirus tumor suppressor gene

Journal

American journal of translational research
ISSN: 1943-8141
Titre abrégé: Am J Transl Res
Pays: United States
ID NLM: 101493030

Informations de publication

Date de publication:
2021
Historique:
received: 10 02 2020
accepted: 28 06 2021
entrez: 15 10 2021
pubmed: 16 10 2021
medline: 16 10 2021
Statut: epublish

Résumé

Cervical cancer (CC) arises from premalignant cervical intraepithelial neoplasia (CIN) induced by a persistent infection with human papillomaviruses. The multi-stepwise disease progression is driven by genetic and epigenetic alterations. Our previous studies demonstrated a clear downregulation of inter-α-trypsin-inhibitor-heavy chain 5 (

Identifiants

pubmed: 34650698
pmc: PMC8507072

Types de publication

Journal Article

Langues

eng

Pagination

10298-10314

Informations de copyright

AJTR Copyright © 2021.

Déclaration de conflit d'intérêts

None.

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Auteurs

Ann-Kathrin Daum (AK)

Department of Gynecology and Reproductive Medicine, Jena University Hospital, Friedrich-Schiller-University Jena, Germany.
Current address: German Cancer Research Center (DKFZ), Division of Cancer Genome Research Heidelberg, Germany.

Jessica Dittmann (J)

Department of Gynecology and Reproductive Medicine, Jena University Hospital, Friedrich-Schiller-University Jena, Germany.

Lars Jansen (L)

Department of Gynecology and Reproductive Medicine, Jena University Hospital, Friedrich-Schiller-University Jena, Germany.

Sven Peters (S)

Department of Ophthalmology, Jena University Hospital, Friedrich-Schiller-University Jena, Germany.

Uta Dahmen (U)

Experimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, Jena University Hospital, Friedrich-Schiller-University Jena, Germany.

Julia I Heger (JI)

Placenta-Lab, Department of Obstetrics, Jena University Hospital, Friedrich-Schiller-University Jena, Germany.

Felix Hoppe-Seyler (F)

Molecular Therapy of Virus-Associated Cancers, German Cancer Research Center (DKFZ) Heidelberg, Germany.

Alexandra Gille (A)

Department of Gynecology and Reproductive Medicine, Jena University Hospital, Friedrich-Schiller-University Jena, Germany.

Joachim H Clement (JH)

Department of Hematology and Medical Oncology, Jena University Hospital, Friedrich-Schiller-University Jena, Germany.

Ingo B Runnebaum (IB)

Department of Gynecology and Reproductive Medicine, Jena University Hospital, Friedrich-Schiller-University Jena, Germany.

Matthias Dürst (M)

Department of Gynecology and Reproductive Medicine, Jena University Hospital, Friedrich-Schiller-University Jena, Germany.

Claudia Backsch (C)

Department of Gynecology and Reproductive Medicine, Jena University Hospital, Friedrich-Schiller-University Jena, Germany.

Classifications MeSH