Dosimetric Impact of Inter-Fraction Anatomical Changes in Carbon Ion Boost Treatment for High-Risk Prostate Cancer (AIRC IG 14300).
carbon ion radiotherapy (CIRT)
deformable image registration (DIR)
dose-of-the-day calculation
high-risk prostate cancer
image-guided radiotherapy (IGRT)
inter-fraction anatomical changes
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
07
2021
accepted:
06
09
2021
entrez:
15
10
2021
pubmed:
16
10
2021
medline:
16
10
2021
Statut:
epublish
Résumé
Rectum and bladder volumes play an important role in the dose distribution reproducibility in prostate cancer adenocarcinoma (PCa) radiotherapy, especially for particle therapy, where density variation can strongly affect the dose distribution. We investigated the reliability and reproducibility of our image-guided radiotherapy (IGRT) and treatment planning protocol for carbon ion radiotherapy (CIRT) within the phase II mixed beam study (AIRC IG 14300) for the treatment of high-risk PCa. In order to calculate the daily dose distribution, a set of synthetic computed tomography (sCT) images was generated from the cone beam computed tomography (CBCT) images acquired in each treatment session. Planning target volume (PTV) together with rectum and bladder volume variation was evaluated with sCT dose-volume histogram (DVH) metric deviations from the planning values. The correlations between the bladder and rectum volumes, and the corresponding DVH metrics, were also assessed. No significant difference in the bladder, rectum, and PTV median volumes between the planning computed tomography (pCT) and the sCT was found. In addition, no significant difference was assessed when comparing the average DVHs and median DVH metrics between pCT and sCT. Dose deviations determined by bladder and rectum filling variations demonstrated that dose distributions were reproducible in terms of both target coverage and organs at risk (OARs) sparing.
Identifiants
pubmed: 34650922
doi: 10.3389/fonc.2021.740661
pmc: PMC8506150
doi:
Types de publication
Journal Article
Langues
eng
Pagination
740661Informations de copyright
Copyright © 2021 Russo, Ricotti, Molinelli, Patti, Barcellini, Mastella, Pella, Paganelli, Marvaso, Pepa, Comi, Zaffaroni, Avuzzi, Giandini, Pignoli, Valdagni, Baroni, Cattani, Ciocca, Jereczek-Fossa, Orlandi, Orecchia and Vischioni.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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