Visualization of Receptor-Interacting Protein Kinase 1 (RIPK1) by Brain Imaging with Positron Emission Tomography.

Animals Brain / diagnostic imaging Dose-Response Relationship, Drug Mice Molecular Structure Positron-Emission Tomography Protein Kinase Inhibitors / chemical synthesis Receptor-Interacting Protein Serine-Threonine Kinases / antagonists & inhibitors Structure-Activity Relationship

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
28 10 2021
Historique:
pubmed: 16 10 2021
medline: 15 12 2021
entrez: 15 10 2021
Statut: ppublish

Résumé

We report the development of the first positron emission tomography (PET) radiotracer, [

Identifiants

DOI: 10.1021/acs.jmedchem.1c01477 PMID: 34652135 PMC: PMC8858444
pubmed: 34652135
doi: 10.1021/acs.jmedchem.1c01477
pmc: PMC8858444
mid: NIHMS1776399
doi:

Substances chimiques

Protein Kinase Inhibitors 0
Receptor-Interacting Protein Serine-Threonine Kinases EC 2.7.11.1
Ripk1 protein, mouse EC 2.7.11.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

15420-15428

Subventions

Organisme : NIH HHS
ID : S10 OD023517
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM128692
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG070141
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG067947
Pays : United States
Organisme : NINDS NIH HHS
ID : R61 NS116423
Pays : United States
Organisme : NIA NIH HHS
ID : R61 AG067916
Pays : United States
Organisme : NINDS NIH HHS
ID : R33 NS116423
Pays : United States

Références

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Auteurs

Yu Lan (Y)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Ping Bai (P)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
ORCID: 0000-0003-4587-8426

Yan Liu (Y)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.

Sepideh Afshar (S)

Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.

Robin Striar (R)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
ORCID: 0000-0003-0490-478X

Anna Kathryn Rattray (AK)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.

Tyler Nicholas Meyer (TN)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.

Amelia G Langan (AG)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.

Alisa M Posner (AM)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.

Shiqian Shen (S)

Department of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 United States.

Rudolph E Tanzi (RE)

Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, Massachusetts 02129, United States.

Can Zhang (C)

Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, Massachusetts 02129, United States.
ORCID: 0000-0002-4340-5118

Changning Wang (C)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
ORCID: 0000-0002-2076-4193

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Classifications MeSH

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