CD300a blockade enhances efferocytosis by infiltrating myeloid cells and ameliorates neuronal deficit after ischemic stroke.
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
15 Oct 2021
15 Oct 2021
Historique:
entrez:
15
10
2021
pubmed:
16
10
2021
medline:
8
3
2022
Statut:
ppublish
Résumé
Immune responses contribute to tissue injury and repair during and after ischemic stroke. However, the spatiotemporal and initiating molecular events remain incompletely understood. Here, we show that mice deficient in the phosphatidylserine receptor CD300a, which is highly expressed on brain myeloid cells including Ly6C
Identifiants
pubmed: 34652960
doi: 10.1126/sciimmunol.abe7915
doi:
Substances chimiques
LMIR1 protein, mouse
0
Receptors, Immunologic
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM