Pulmonary macrophages and their different roles in health and disease.
Alveolar macrophages
Inflammation
Interstitial macrophages
Lung disease
Lung infection
Journal
The international journal of biochemistry & cell biology
ISSN: 1878-5875
Titre abrégé: Int J Biochem Cell Biol
Pays: Netherlands
ID NLM: 9508482
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
14
07
2021
revised:
08
10
2021
accepted:
10
10
2021
pubmed:
16
10
2021
medline:
17
12
2021
entrez:
15
10
2021
Statut:
ppublish
Résumé
Macrophages are a heterogeneous population of myeloid cells with phenotype and function modulated according to the microenvironment in which they are found. The lung resident macrophages known as Alveolar Macrophages (AM) and Interstitial Macrophages (IM) are localized in two different compartments. During lung homeostasis, macrophages can remove inhaled particulates, cellular debris and contribute to some metabolic processes. Macrophages may assume a pro-inflammatory phenotype after being classically activated (M1) or anti-inflammatory when being alternatively activated (M2). M1 and M2 have different transcription profiles and act by eliminating bacteria, viruses and fungi from the host or repairing the damage triggered by inflammation, respectively. Nevertheless, macrophages also may contribute to lung damage during persistent inflammation or continuous exposure to antigens. In this review, we discuss the origin and function of pulmonary macrophages in the context of homeostasis, infectious and non-infectious lung diseases.
Identifiants
pubmed: 34653619
pii: S1357-2725(21)00176-X
doi: 10.1016/j.biocel.2021.106095
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106095Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.