Hydrogen-bonded silicene nanosheets of engineered bandgap and selective degradability for photodynamic therapy.

Humans Hydrogen Neoplasms / drug therapy Photochemotherapy Silicon Tumor Microenvironment
Bandgap engineering Degradability Hydrogenation Photodynamic therapy Silicene

Journal

Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316

Informations de publication

Date de publication:
11 2021
Historique:
received: 14 08 2021
revised: 27 09 2021
accepted: 30 09 2021
pubmed: 16 10 2021
medline: 16 11 2021
entrez: 15 10 2021
Statut: ppublish

Résumé

Silicon, a highly biocompatible and ubiquitous chemical element in living systems, exhibits great potentials in biomedical applications. However, the silicon-based nanomaterials such as silica and porous silicon have been largely limited to only serving as carriers for delivery systems, due to the lack of intrinsic functionalities of silicon. This work presents the facile construction of a two-dimensional (2D) hydrogen-bonded silicene (H-silicene) nanosystem which is highlighted with tunable bandgap and selective degradability for tumor-specific photodynamic therapy facilely by surface covalent modification of hydrogen atoms. Briefly, the H-silicene nanosheet material is selectively degradable in normal neutral tissues but rather stable in the mildly acidic tumor microenvironment (TME) for achieving efficient photodynamic therapy (PDT). Such a 2D hydrogen-bonded silicene nanosystem featuring the tunable bandgap and tumor-selective degradability provides a new paradigm for the application of multi-functional two-dimensional silicon-based biomaterials towards the diagnosis and treatments of cancer and other diseases.

Identifiants

DOI: 10.1016/j.biomaterials.2021.121172 PMID: 34653935
pubmed: 34653935
pii: S0142-9612(21)00529-9
doi: 10.1016/j.biomaterials.2021.121172
pii:
doi:

Substances chimiques

Hydrogen 7YNJ3PO35Z
Silicon Z4152N8IUI

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

121172

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Deliang Xu (D)

State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China; School of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, PR China.

Han Lin (H)

State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China; Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, PR China. Electronic address: linhan@mail.sic.ac.cn.

Wujie Qiu (W)

State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.

Min Ge (M)

State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.

Zhixin Chen (Z)

State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.

Chenyao Wu (C)

State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.

Yanling You (Y)

State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.

Xiangyu Lu (X)

State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.

Chenyang Wei (C)

State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.

Jianjun Liu (J)

State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.

Xiang Guo (X)

Department of Orthopedics, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, PR China. Electronic address: gx9601074@smmu.edu.cn.

Jianlin Shi (J)

State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China; Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, PR China. Electronic address: jlshi@mail.sic.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hydrogen-bonded silicene nanosheets of...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Hydrogène › Hydrogen-bonded silicene nanosheets of...
questionsmedicales.fr › Tumeurs › Hydrogen-bonded silicene nanosheets of...
questionsmedicales.fr › Thérapeutique › Photothérapie › Photothérapie dynamique › Hydrogen-bonded silicene nanosheets of...
questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Métalloïdes › Silicium › Hydrogen-bonded silicene nanosheets of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Hydrogen-bonded silicene nanosheets of...