Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology.
Animals
Cardiovascular System
/ pathology
Cell Physiological Phenomena
Cells, Cultured
Chlorides
/ metabolism
Circadian Rhythm
/ physiology
Fibroblasts
Homeostasis
Ion Transport
/ physiology
Lung
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Osmosis
Potassium
/ metabolism
Proteome
Sodium
/ metabolism
Solute Carrier Family 12, Member 2
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
15 10 2021
15 10 2021
Historique:
received:
26
05
2020
accepted:
04
08
2021
entrez:
16
10
2021
pubmed:
17
10
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Between 6-20% of the cellular proteome is under circadian control and tunes mammalian cell function with daily environmental cycles. For cell viability, and to maintain volume within narrow limits, the daily variation in osmotic potential exerted by changes in the soluble proteome must be counterbalanced. The mechanisms and consequences of this osmotic compensation have not been investigated before. In cultured cells and in tissue we find that compensation involves electroneutral active transport of Na
Identifiants
pubmed: 34654800
doi: 10.1038/s41467-021-25942-4
pii: 10.1038/s41467-021-25942-4
pmc: PMC8520019
doi:
Substances chimiques
Chlorides
0
Proteome
0
Slc12a2 protein, mouse
0
Solute Carrier Family 12, Member 2
0
Sodium
9NEZ333N27
Potassium
RWP5GA015D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6035Subventions
Organisme : Medical Research Council
ID : MC_U105184326
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1201/4
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 208790/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1201/13
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021. Crown.
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